338773-34-5 Usage
Description
8-Chloro-6-(trifluoromethyl)[1,2,4]triazolo[4,3-a]pyridin-3-amine is a chemical compound with a unique structure that features a triazolopyridine core, a chloro substituent, and a trifluoromethyl group. 8-CHLORO-6-(TRIFLUOROMETHYL)[1,2,4]TRIAZOLO[4,3-A]PYRIDIN-3-AMINE is characterized by its potential as a reagent in biological studies, particularly in the field of fragment screening.
Uses
Used in Pharmaceutical Research:
8-Chloro-6-(trifluoromethyl)[1,2,4]triazolo[4,3-a]pyridin-3-amine is used as a reagent for the biological study of fragment screening of N-Acetylmannosamine kinase. This enzyme plays a crucial role in the biosynthesis of N-acetylneuraminic acid, which is an essential component of various biological processes. 8-CHLORO-6-(TRIFLUOROMETHYL)[1,2,4]TRIAZOLO[4,3-A]PYRIDIN-3-AMINE aids researchers in identifying potential drug candidates that can modulate the activity of N-Acetylmannosamine kinase, thereby contributing to the development of novel therapeutic agents for various diseases.
Used in Drug Discovery:
In the field of drug discovery, 8-chloro-6-(trifluoromethyl)[1,2,4]triazolo[4,3-a]pyridin-3-amine serves as a valuable tool for the identification and optimization of lead compounds. Its unique chemical properties and interaction with target proteins make it a promising starting point for the design of new drugs with improved efficacy and selectivity.
Used in Chemical Synthesis:
8-Chloro-6-(trifluoromethyl)[1,2,4]triazolo[4,3-a]pyridin-3-amine can also be utilized in chemical synthesis for the preparation of various derivatives and analogs. These synthesized compounds can be further explored for their potential applications in medicinal chemistry, materials science, and other related fields.
Check Digit Verification of cas no
The CAS Registry Mumber 338773-34-5 includes 9 digits separated into 3 groups by hyphens. The first part of the number,starting from the left, has 6 digits, 3,3,8,7,7 and 3 respectively; the second part has 2 digits, 3 and 4 respectively.
Calculate Digit Verification of CAS Registry Number 338773-34:
(8*3)+(7*3)+(6*8)+(5*7)+(4*7)+(3*3)+(2*3)+(1*4)=175
175 % 10 = 5
So 338773-34-5 is a valid CAS Registry Number.
338773-34-5Relevant articles and documents
HETEROCYCLIC COMPOUNDS FOR THE CONTROL OF INVERTEBRATE PESTS
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, (2021/11/20)
The invention relates to compounds of formula (I) wherein the variables have the meanings as defined in the specification, to compositions comprising them, to active compound combinations comprising them, and to their use for protecting growing plants and
Oxidative cyclization of 1-(pyridin-2-yl)guanidine derivatives: A synthesis of [1,2,4]triazolo[1,5-a]pyridin-2-amines and an unexpected synthesis of [1,2,4]triazolo[4,3-a]pyridin-3-amines
Ishimoto, Kazuhisa,Nagata, Toshiaki,Murabayashi, Mika,Ikemoto, Tomomi
, p. 407 - 418 (2015/03/03)
Oxidative cyclization of 1-(pyridin-2-yl)guanidine derivatives using N-chlorosuccinimide and aqueous potassium carbonate has been investigated. Chlorination of 1-(5-nitropyridin-2-yl)guanidine by N-chlorosuccinimide in methanol followed by addition of aqueous potassium carbonate gave rise to cyclization and afforded 6-nitro-[1,2,4]triazolo[1,5-a]pyridin-2-amine in one-pot. In the course of studying the scope and limitation of the reaction, it was found that some of the examined 1-(pyridin-2-yl)guanidine derivatives gave not only the desired [1,2,4]triazolo[1,5-a]pyridin-2-amines but also unexpected [1,2,4]triazolo[4,3-a]pyridin-3-amine products. As plausible reaction mechanisms of this oxidative cyclization, diazirine formation and nitrene formation are presented.
