33889-69-9

Basic information

• Product Name: Silicristin
• Synonyms: SILYCHRISTIN;SILYCRISTIN;SILICHRISTIN;Silicristin;SILYCHRISTIN hplc;4H-1-Benzopyran-4-one,2-[(2R, 3S)-2,3-dihydro-7-;hydroxy-2-(4-hydroxy-3-methoxyphenyl)-3-(hydroxymethyl)-5-benzofuranyl]-2,3-dihydro-3,5,7-trihydroxy-,(2R,3R)-;Silychristin A
• CAS NO: 33889-69-9
• Molecular Formula: C₂₅H₂₂O₁₀
• Molecular Weight: 482.44
• EINECS: 251-720-9
• Product Categories: Miscellaneous Natural Products;chemical reagent;pharmaceutical intermediate;phytochemical;reference standards from Chinese medicinal herbs (TCM).;standardized herbal extract
• Mol File: 33889-69-9.mol
• Article Data: 2

Chemical Properties

• Melting Point: 174～176℃
• Boiling Point: 782oC at 760 mmHg
• Flash Point: 270.5oC
• Appearance: /
• Density: 1.578g/cm3
• Vapor Pressure: 9.44E-26mmHg at 25°C
• Refractive Index: 1.716
• Storage Temp.: 2-8°C
• Solubility: Acetone (Slightly), Methanol (Slightly)
• PKA: 7.39±0.60(Predicted)
• CAS DataBase Reference: Silicristin(CAS DataBase Reference)
• NIST Chemistry Reference: Silicristin(33889-69-9)
• EPA Substance Registry System: Silicristin(33889-69-9)

Safety Data

• Hazard Codes: Xn
• Statements: 22
• Safety Statements: 22-45
• WGK Germany: 3
• Hazardous Substances Data: 33889-69-9(Hazardous Substances Data)

Usage

Description

Silicristin is a natural product isolated from silymarin, the hepatoprotective extract of milk thistle (Silybum marianum) fruits. It is an antihepatotoxic flavonolignan, which means it has protective properties for the liver.
Used in Pharmaceutical Industry:
Silicristin is used as a hepatoprotective agent for its ability to protect the liver from damage and toxicity. Its antihepatotoxic properties make it a valuable component in the development of medications and supplements aimed at liver health and support.

InChI:InChI=1/C25H22O10/c1-33-18-6-10(2-3-15(18)28)23-14(9-26)13-4-11(5-17(30)25(13)35-23)24-22(32)21(31)20-16(29)7-12(27)8-19(20)34-24/h2-8,14,22-24,26-30,32H,9H2,1H3/t14-,22+,23+,24-/m1/s1

Upstream product

• 119384-64-4 3,4-dibenzyloxy-5-formylbenzaldehyde dimethyl acetal 
• 119384-63-3 5-bromo-3,4-benzyloxybenzaldehyde dimethyl acetal 
• 124662-50-6 3,4-Bis(benzyloxy)-5-brombenzaldehyd 
• 36804-11-2 2,4,6-tri-MOM phloracetophenone 
• 480-66-0 2,4,6-trihydroxyacetophenone 
• 16414-34-9 3-bromo-4,5-dihydroxybenzaldehyde 
• 119384-70-2 (E)-3-[(2S,3R)-7-Methoxymethoxy-2-(3-methoxy-4-methoxymethoxy-phenyl)-3-methoxymethoxymethyl-2,3-dihydro-benzofuran-5-yl]-1-(2,4,6-tris-methoxymethoxy-phenyl)-propenone 
• 119384-65-5 1-(4-benzyloxy-3-methoxyphenyl)-3-(2,3-dibenzyloxy-5-dimethoxymethylphenyl)-2-propen-1-one 
• 119384-66-6 1-(4-benzyloxy-3-methoxyphenyl)-3-(2,3-dibenzyloxy-5-formylphenyl)-2,3-epoxy-1-propanone 
• 119389-99-0 1-(4-Benzyloxy-3-methoxy-phenyl)-2-(2,3-bis-benzyloxy-5-hydroxymethyl-phenyl)-propane-1,3-diol 
• 124662-51-7 1-(4-benzyloxy-3-methoxyphenyl)-3-(2,3-dibenzyloxy-5-formylphenyl)-2-propen-1-one 
• 124662-57-3 Acetic acid (2S,3R)-7-methoxymethoxy-2-(3-methoxy-4-methoxymethoxy-phenyl)-3-methoxymethoxymethyl-2,3-dihydro-benzofuran-5-ylmethyl ester 
• 119390-00-0 (2S,3R)-7-Methoxymethoxy-2-(3-methoxy-4-methoxymethoxy-phenyl)-3-methoxymethoxymethyl-2,3-dihydro-benzofuran-5-carbaldehyde 
• 124662-58-4 [(2S,3R)-7-Methoxymethoxy-2-(3-methoxy-4-methoxymethoxy-phenyl)-3-methoxymethoxymethyl-2,3-dihydro-benzofuran-5-yl]-methanol 

Downstream Products

• 55607-52-8 isohydnocarpin 
• 57499-41-9 2,3-dehydrosilychristin A 

Relevant articles and documents

Total synthesis of silychristin, an antihepatotoxic flavonolignan

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