338992-00-0 Usage
Description
VANDETANIB, also known as Zactima, is a potent and selective inhibitor of multiple receptor tyrosine kinases (RTKs), including vascular endothelial growth factor receptor (VEGFR), epidermal growth factor receptor (EGFR), and RET proto-oncogene. It is a small molecule drug developed by AstraZeneca and has demonstrated significant anti-tumor activity by inhibiting angiogenesis and tumor cell proliferation. VANDETANIB is characterized by its ability to target multiple signaling pathways involved in cancer progression, making it a promising therapeutic agent for various types of cancer.
Uses
Used in Oncology:
VANDETANIB is used as an anti-cancer agent for the treatment of non-small cell lung cancer (NSCLC) and other solid tumors. It works by inhibiting the activity of multiple receptor tyrosine kinases, which are often overexpressed or mutated in cancer cells, leading to uncontrolled cell growth and angiogenesis. By targeting these pathways, VANDETANIB can effectively suppress tumor growth and progression.
Used in Drug Development:
VANDETANIB serves as a valuable compound in the development of novel cancer therapies. Its ability to inhibit multiple RTKs makes it an attractive candidate for combination therapies, where it can be used alongside other targeted agents or conventional chemotherapy to enhance treatment efficacy and overcome drug resistance.
Used in Research:
VANDETANIB is also utilized in various research applications, such as in vitro and in vivo studies, to investigate the role of receptor tyrosine kinases in cancer biology and to identify potential therapeutic targets for the development of new anti-cancer drugs.
Check Digit Verification of cas no
The CAS Registry Mumber 338992-00-0 includes 9 digits separated into 3 groups by hyphens. The first part of the number,starting from the left, has 6 digits, 3,3,8,9,9 and 2 respectively; the second part has 2 digits, 0 and 0 respectively.
Calculate Digit Verification of CAS Registry Number 338992-00:
(8*3)+(7*3)+(6*8)+(5*9)+(4*9)+(3*2)+(2*0)+(1*0)=180
180 % 10 = 0
So 338992-00-0 is a valid CAS Registry Number.
InChI:InChI=1/C22H24BrFN4O2/c1-28-7-5-14(6-8-28)12-30-21-11-19-16(10-20(21)29-2)22(26-13-25-19)27-18-4-3-15(23)9-17(18)24/h3-4,9-11,13-14H,5-8,12H2,1-2H3,(H,25,26,27)
