339-93-5

Basic information

• Product Name: [2-(trifluoromethyl)phenyl]glycolic acid
• Synonyms: [2-(trifluoromethyl)phenyl]glycolic acid;o-Trifluoromethylmandelic acid;α-Hydroxy-2-(trifluoromethyl)benzeneacetic acid;2-hydroxy-2-[2-(trifluoromethyl)phenyl]acetic acid;2-hydroxy-2-[2-(trifluoromethyl)phenyl]ethanoic acid;Hydroxy-(2-trifluoromethyl-phenyl)-acetic acid
• CAS NO: 339-93-5
• Molecular Formula: C₉H₇F₃O₃
• Molecular Weight: 220.1452896
• EINECS: 206-428-6
• Mol File: 339-93-5.mol
• Article Data: 7

Chemical Properties

• Boiling Point: 314.5°C at 760 mmHg
• Flash Point: 144°C
• Appearance: /
• Density: 1.481g/cm³
• Vapor Pressure: 0.000197mmHg at 25°C
• Refractive Index: 1.502
• PKA: 3.24±0.10(Predicted)
• CAS DataBase Reference: [2-(trifluoromethyl)phenyl]glycolic acid(CAS DataBase Reference)
• NIST Chemistry Reference: [2-(trifluoromethyl)phenyl]glycolic acid(339-93-5)
• EPA Substance Registry System: [2-(trifluoromethyl)phenyl]glycolic acid(339-93-5)

Safety Data

• Hazardous Substances Data: 339-93-5(Hazardous Substances Data)

Usage

General Description

The chemical [2-(trifluoromethyl)phenyl]glycolic acid is a compound belonging to the class of phenylglycolic acids. It is characterized by the presence of a trifluoromethyl group and a phenyl group attached to a glycolic acid backbone. [2-(trifluoromethyl)phenyl]glycolic acid has potential applications in pharmaceuticals, agrochemicals, and materials science due to its unique structure and properties. Specifically, its trifluoromethyl group is known to enhance the biological and chemical activities of the molecule, making it a valuable building block in drug discovery and development. Additionally, the presence of the glycolic acid moiety may confer unique solubility and reactivity properties to the compound, allowing for diverse applications in various fields of chemistry and chemical engineering.

InChI:InChI=1/C9H7F3O3/c10-9(11,12)6-4-2-1-3-5(6)7(13)8(14)15/h1-4,7,13H,(H,14,15)

Upstream product

• 75-25-2 Bromoform 
• 447-61-0 2-Trifluoromethylbenzaldehyde 
• 124-38-9 carbon dioxide 

Downstream Products

• 181039-99-6 methyl 2-bromo-2-(2-(trifluoromethyl)phenyl)acetate 
• 181040-26-6 methyl (RS)-[2-cyano-5-(thien-3-ylmethoxy)phenoxy]-(2-trifluoromethylphenyl)acetate 
• 181040-01-7 methyl (RS)-[5-(1,3-benzodioxol-5-ylmethoxy)-2-cyanophenoxy]-(2-trifluoromethylphenyl)acetate 

Relevant articles and documents

Photocatalytic Carbinol Cation/Anion Umpolung: Direct Addition of Aromatic Aldehydes and Ketones to Carbon Dioxide

We have developed a new photocatalytic umpolung reaction of carbonyl compounds to generate anionic carbinol synthons. Aromatic aldehydes or ketones reacted with carbon dioxide in the presence of an iridium photocatalyst and 1,3-dimethyl-2-phenyl-2,3-dihydro-1H-benzimidazole (DMBI) as a reductant under visible-light irradiation to furnish the corresponding α-hydroxycarboxylic acids through nucleophilic addition of the resulting carbinol anions to electrophilic carbon dioxide.

Anti-viral compounds

The present invention relates to compounds of Formula (I) below, which inhibit the growth of picornaviruses, Hepatitus viruses, enteroviruses, cardioviruses, polioviruses, coxsackieviruses of the A and B groups, echo virus and Mengo virus. wherein: A is phenyl, pyridyl, substituted phenyl, substituted pyridyl, or benzyl; R is hydrogen, COR4, or COCF3; X is N—OH, O, or CHR1; R1is hydrogen, halo, CN, C1-C4alkyl, —C≡CH, CO(C1-C4alkyl), CO2(C1-C4alkyl), or CONR2R3; R2and R3are independently hydrogen or C1-C4alkyl; A′ is hydrogen, halo, C1-C6alkyl, benzyl, naphthyl, thienyl, furyl, pyridyl, pyrollyl, COR4, S(O)nR4, or a group of the formula R4is C1-C6alkyl, phenyl, or substituted phenyl; n is 0, 1, or 2; R5is independently at each occurrence hydrogen or halo; m is 1, 2, 3, or 4; and R6is hydrogen, halo, CF3, OH, CO2H, NH2, NO2, CONHOCH3, C1-C4alkyl, or CO2(C1-C4alkyl), C1-C4alkoxy; or a pharmaceutically acceptable salt thereof.

7-α-Amino-substituted acylamino-3-(1-carboxymethyltetrazol-5-ylthiomethyl)-3-cephem-4-carboxylic acids

Certain 7-acylamido-3-(1-carboxy-loweralkyl-tetrazol-5-ylthiomethyl)-3-cephem-4-carboxylic acids and their salts and easily hydrolyzed esters of the 4-carboxyl group were synthesized and found to be potent antibacterial agents which exhibited good aqueous solubility. In a preferred embodiment the 7-substituent was 2'-aminomethylphenylacetamido.