33934-11-1

Basic information

• Product Name: N-Methyl-3-phenylisoxazolidine-5-one
• Synonyms: N-Methyl-3-phenylisoxazolidine-5-one
• CAS NO: 33934-11-1
• Molecular Weight: 177.203
• Mol File: 33934-11-1.mol
• Article Data: 5

Chemical Properties

• CAS DataBase Reference: N-Methyl-3-phenylisoxazolidine-5-one(CAS DataBase Reference)
• NIST Chemistry Reference: N-Methyl-3-phenylisoxazolidine-5-one(33934-11-1)
• EPA Substance Registry System: N-Methyl-3-phenylisoxazolidine-5-one(33934-11-1)

Safety Data

• Hazardous Substances Data: 33934-11-1(Hazardous Substances Data)

Upstream product

• 102-92-1 Cinnamoyl chloride 
• 103-26-4 Methyl cinnamate 
• 593-77-1 N-Methylhydroxylamine 
• 86933-55-3 N-methylcinnamohydroxamic acid 
• 29900-75-2 trans-cinnamohydroxamic acid 
• 3376-23-6 N-methyl-α-phenylnitrone 
• 105-36-2 ethyl bromoacetate 
• 5292-43-3 bromoacetic acid tert-butyl ester 
• 215236-87-6 5-Acetoxy-N-methyl-3-phenylisoxazolidine 
• 3376-23-6 C-phenyl-N-methylnitrone 
• 215236-89-8 2-Methyl-3-phenyl-5-hydroxyisoxazolidine 

Downstream Products

• 103-26-4 methyl cinnamate 

Relevant articles and documents

Reaction of 2-alkylidene-3,1-benzoxathiin-4-ones with nitrones

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Asymmetric Syntheses of the Naturally Ocurring β-Amino Acids, β-Lysine, β-Leucine and β-Phenyl-β-alanine via Nitrone Cycloaddition

A general asymmetric synthesis of β-amino acids is based on the dipolar cycloaddition of nitrones 7 (R* chiral) with vinyl acetate 8a, ketene acetals 8b or α-chloroacrylonitrile 8c.The cycloadducts 9 are converted either directly (9b) or via the isoxazolidones 10 (9a, 9c) into the free β-amino acids 11.Diastereoselectivity at C-3 in the adducts 9 ranges between 2:1 and 11:1.The natural β-amino acids, β-lysine, β-leucine and β-phenyl-β-alanine, have been prepared in this way.

Method for the production of N-alkyl beta-hydroxylamine hydrocinnamonyl hydroxamic acids

The subject invention is directed to a method of making compounds having the formula: STR1 wherein R1 is alkyl, R2 is H or alkyl, R3 and R4 are H, halogen, amino, alkylamino, alkoxy, alkyl, OH, O, NO2 or combinations thereof, and X is CH or N, which compounds are useful as antihypertensive agents.