3398-68-3 Usage
Description
p-methoxy-N,alpha-dimethylphenethylamine hydrochloride, also known as PMMA or para-methoxymethamphetamine, is a stimulant and psychedelic drug closely related to the amphetamine PMA. It is a designer drug that is sometimes used as a substitute for the amphetamine MDMA. PMMA is a 4-methoxy analog of methamphetamine and is classified as a controlled substance due to its psychoactive effects on the central nervous system (CNS).
Uses
Used in Clinical Toxicology and Forensic Analysis:
p-methoxy-N,alpha-dimethylphenethylamine hydrochloride is used as a Certified Spiking Solution for LC/MS or GC/MS amphetamine testing methods. This application is essential for ensuring the accuracy and reliability of drug testing in clinical toxicology, forensic analysis, and urine drug testing.
Used in Research and Development:
As a stimulant and psychedelic drug, PMMA is used in research and development for understanding its effects on the CNS and potential applications in the pharmaceutical industry. This includes studying its interactions with various neurotransmitter systems and exploring its potential therapeutic uses.
Used in Drug Enforcement and Control:
Due to its classification as a controlled substance, p-methoxy-N,alpha-dimethylphenethylamine hydrochloride is used by law enforcement agencies and regulatory bodies to monitor and control its distribution, sale, and use. This helps in preventing the misuse and abuse of this potent psychoactive drug.
Check Digit Verification of cas no
The CAS Registry Mumber 3398-68-3 includes 7 digits separated into 3 groups by hyphens. The first part of the number,starting from the left, has 4 digits, 3,3,9 and 8 respectively; the second part has 2 digits, 6 and 8 respectively.
Calculate Digit Verification of CAS Registry Number 3398-68:
(6*3)+(5*3)+(4*9)+(3*8)+(2*6)+(1*8)=113
113 % 10 = 3
So 3398-68-3 is a valid CAS Registry Number.
3398-68-3Relevant articles and documents
Involvement of CYP2D6 in the in vitro metabolism of amphetamine, two N-alkylamphetamines and their 4-methoxylated derivatives
Bach, Mimi V.,Coutts,Baker
, p. 719 - 732 (2007/10/03)
1. Amphetamine (AM) and five amphetamine derivatives, N-ethylamphetamine (NEA), N-butylamphetamine (NBA), 4-methoxyamphetamine (M-AM), 4-methoxy-N-ethylamphetamine (M-NEA) and 4-methoxy-N-butylamphetamine (M-NBA) were incubated with microsomal preparations from cells expressing human CYP2D6 to determine whether the enzyme was capable of catalyzing the direct ring oxidation of all substrates; the N-dealkylation of NEA, NBA, M-NEA and M-NBA; and the O-demethylation of M-AM, M-NEA and M-NBA. 2. None of the six compounds examined was N-dealkylated to any extent. 3. The only metabolites produced from AM, NEA and NBA were the corresponding ring 4-hydroxylated compounds, and the rates of formation were low. 4. All ring 4-methoxylated substrates were efficiently O-demethylated by CYP2D6 to their corresponding phenols. The size of the N-alkyl group influenced the rates of formation of these phenolamines. In contrast to reported findings with 2- and 3-methoxyamphetamines, none of the 4-methoxyamphetamines was ring-oxidized in the CYP2D6 enzyme system to 2- or 3-hydroxy-4-methoxyamphetamines or to dihydroxy-amphetamines.
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