340142-53-2

Basic information

• Product Name: Propanedinitrile, [2,6-bis[2-[4-[(2-hydroxyethyl)methylamino]phenyl]ethenyl]-4H-pyran-4-yl idene]-
• CAS NO: 340142-53-2
• Molecular Formula: C30H30N4O3
• Molecular Weight: 494.593
• Mol File: 340142-53-2.mol
• Article Data: 2

Chemical Properties

• CAS DataBase Reference: Propanedinitrile, [2,6-bis[2-[4-[(2-hydroxyethyl)methylamino]phenyl]ethenyl]-4H-pyran-4-yl idene]-(CAS DataBase Reference)
• NIST Chemistry Reference: Propanedinitrile, [2,6-bis[2-[4-[(2-hydroxyethyl)methylamino]phenyl]ethenyl]-4H-pyran-4-yl idene]-(340142-53-2)
• EPA Substance Registry System: Propanedinitrile, [2,6-bis[2-[4-[(2-hydroxyethyl)methylamino]phenyl]ethenyl]-4H-pyran-4-yl idene]-(340142-53-2)

Safety Data

• Hazardous Substances Data: 340142-53-2(Hazardous Substances Data)

Upstream product

• 28286-88-6 4-dicyanomethylene-2,6-dimethyl-4H-pyran 
• 1201-91-8 4-(N-methyl-N-hydroxyethylamino)benzaldehyde 

Downstream Products

• 1565841-55-5 2-bromo-2-methylpropionic acid 2-{[4-(2-{6-[2-(4-{[2-(2-bromo-2-methylpropionyloxy)ethyl]methylamino}phenyl)vinyl]-4-dicyanomethylene-4H-pyran-2-yl}vinyl)phenyl]methylamino}ethyl ester 

Relevant articles and documents

D-A-D fluorogenic probe for the rapid imaging of amyloid β plaques in?vivo

The effective imaging of amyloid β (Aβ) in?vivo is important for the diagnosis of Aβ-related diseases such as the Alzheimer's disease (AD). Here we report a donor-acceptor-donor (D-A-D) type fluorogenic probe for the rapid imaging of amyloid β (Aβ) senile plaques in a transgenic mouse brain. The probe that features a dicyanomethylene-4H-pyran (DCM) core shows a concentration-dependent fluorescence enhancement with Aβ42 and Aβ40, which are the main components of Aβ fibrils formed in the brain of AD patients. The D-A-D probe can also be used to rapidly sense Aβ peptide monomer, oligomer and fibril in an aqueous solution and image the morphologically diverse Aβ species by confocal microscopy. In particular, we demonstrate that the probe can be used to rapidly stain Aβ senile plaques in the brain of transgenic mice by intravenous injection.