3403-82-5

Basic information

• Product Name: 4,4'-oxybisbutan-1-ol
• Synonyms: 4,4'-oxybisbutan-1-ol;4,4'-Oxybis(1-butanol);Einecs 222-280-5
• CAS NO: 3403-82-5
• Molecular Formula: C₈H₁₈O₃
• Molecular Weight: 162.22672
• EINECS: 222-280-5
• Mol File: 3403-82-5.mol
• Article Data: 7

Chemical Properties

• Boiling Point: 274.5°Cat760mmHg
• Flash Point: 119.8°C
• Appearance: /
• Density: 1.001g/cm³
• Storage Temp.: Hygroscopic, Refrigerator, Under inert atmosphere
• Solubility: Chloroform (Slightly), Methanol (Slightly)
• PKA: 14.77±0.10(Predicted)
• Stability: Hygroscopic
• CAS DataBase Reference: 4,4'-oxybisbutan-1-ol(CAS DataBase Reference)
• NIST Chemistry Reference: 4,4'-oxybisbutan-1-ol(3403-82-5)
• EPA Substance Registry System: 4,4'-oxybisbutan-1-ol(3403-82-5)

Safety Data

• HazardClass: IRRITANT
• Hazardous Substances Data: 3403-82-5(Hazardous Substances Data)

Usage

General Description

4,4'-oxybisbutan-1-ol, also known as diethylene glycol monobutyl ether, is a chemical compound primarily used as a solvent in various industrial applications. It is a colorless liquid with a mild, pleasant odor, and it is commonly used in the production of paints, coatings, and inks. It is also utilized in the manufacturing of household and personal care products, such as cleaners and detergents. Additionally, 4,4'-oxybisbutan-1-ol can be found in some pesticide formulations, hydraulic fluids, and as a solvent in the pharmaceutical industry. However, it is important to handle this chemical with care, as it can be harmful if ingested or inhaled, and it may cause skin and eye irritation. Therefore, proper safety precautions should be taken when working with 4,4'-oxybisbutan-1-ol.

Upstream product

• 6334-96-9 bis-(4-chlorobutyl)ether 
• 5373-91-1 5-oxa-nonanedioic acid dimethyl ester 
• 71-36-3 butan-1-ol 
• 110-63-4 Butane-1,4-diol 
• 928-88-1 4-(4-acetoxybutoxy)butyl acetate 

Downstream Products

• 1708-29-8 2,5-dihydrofuran 
• 5392-06-3 6-oxa-undecanedinitrile 

Relevant articles and documents

Synthesis method of 5-oxa-nonanedioic acid

The invention relates to a synthesis method of 5-oxa-nonanedioic acid, and mainly solves the technical problem of lack of effective synthesis methods of 5-oxa-nonanedioic acid. The synthesis method provided by the invention comprises the following steps: under protection of nitrogen, adding 4-bromobutyl benzyl ether into a dimethylsulfoxide (DMSO) solution of 1,4-butanediol and potassium hydroxideto generate a compound 1; carrying out catalytic debenzylation on the compound 1 by Pd/C in methanol in a hydrogen environment to generate a compound 2; and oxidizing the compound 2 by a Jones reagent in acetone to produce a target compound 3. The reaction formula is as follows. The synthesis method has the advantages of short reaction time, mild reaction, high product purity and high yield.

Steroidal bivalent ligands for the estrogen receptor: Design, synthesis, characterization and binding affinities

Steroidal bivalent ligands for the estrogen receptor (ER) were designed using crystal structures of ERα dimers as a template. The syntheses of several 17α-ethynylestradiol-based bivalent ligands with varying linker compositions and lengths are described. The binding affinities of these bivalent ligands for ERα and ERβ were determined. In the two series of bivalent ligands that we synthesized, there is a clear correlation between linker length and binding affinity, both of which reach a maximum at the same tether length. Further studies are underway to explore aspects of bivalent ligand and control compound binding to the ERs and their effects on ER dimer formation; these results will be reported in a subsequent publication.