3405-77-4 Usage
Description
5-Methylisoxazole-3-carboxylic acid is an organic compound that serves as a metabolite of UTL-5b, a structural analog of the anti-arthritic drug Leflunomide (L322750). It is an off-white solid with various applications in the pharmaceutical and chemical industries due to its unique chemical properties.
Uses
Used in Pharmaceutical Industry:
5-Methylisoxazole-3-carboxylic acid is used as a reactant for Click/aza-Michael or Click/oligomeric alkyl carbodiimide esterification reactions, which are crucial in the synthesis of various pharmaceutical compounds.
Used in Anticancer Applications:
In the field of oncology, 5-Methylisoxazole-3-carboxylic acid is used as a reactant for the preparation of aminopyrazole amide derivatives. These derivatives act as Raf kinase inhibitors, playing a significant role in the treatment of melanoma cells.
Used in Synthesis of Heterocycle-Bearing Polyfunctionalized Pyrroles:
5-Methylisoxazole-3-carboxylic acid is also utilized in the preparation of trifluoromethoxyphenyl(thiazolyl)pyrroles and other heterocycle-bearing polyfunctionalized pyrroles. These compounds are essential in the development of new drugs and materials with diverse applications.
Used in Chemical Synthesis:
As a versatile reactant, 5-Methylisoxazole-3-carboxylic acid is employed in various chemical synthesis processes, contributing to the development of new compounds and materials with potential applications in different industries.
Check Digit Verification of cas no
The CAS Registry Mumber 3405-77-4 includes 7 digits separated into 3 groups by hyphens. The first part of the number,starting from the left, has 4 digits, 3,4,0 and 5 respectively; the second part has 2 digits, 7 and 7 respectively.
Calculate Digit Verification of CAS Registry Number 3405-77:
(6*3)+(5*4)+(4*0)+(3*5)+(2*7)+(1*7)=74
74 % 10 = 4
So 3405-77-4 is a valid CAS Registry Number.
InChI:InChI=1/C5H5NO3/c1-3-2-4(5(7)8)6-9-3/h2H,1H3,(H,7,8)
3405-77-4Relevant articles and documents
The first coordination compound with 5-methylisoxazole-3-carboxylate: Synthesis and structural characterization of [Cu(L2)(H2O)] ... H2O
Birk, Torben,Weihe, Hogni
, p. 766 - 771 (2009)
The title compound, aquabis(5-methylisoazole-3-carboxylato-O,N)copper(II) monohydrate, [Cu(L2)(H2O)] ... H2O is synthesized and characterized by X-ray diffraction, elementary analysis, and IR. The ligand coordinates to the
Enaminones 12. An explanation of anticonvulsant activity and toxicity per Linus Pauling's clathrate hypothesis
Jackson, Patrice L.,Hanson, Clive D.,Farrell, Alanna K.,Butcher, Raymond J.,Stables, James P.,Eddington, Natalie D.,Scott
experimental part, p. 42 - 51 (2012/07/28)
The x-ray crystal structure of 3-((5-methylisoxazol-3-yl)amino)-5- methylcyclohex-2-enone (12b) and 3-((5-methylisoxazolyl-3-yl)amino)-5,5- dimethylcyclohex-2-enone (12c) were determined and correlated to their anticonvulsant activity in mice and rats. A hypothesis for the toxicity of the analogs are advanced. In addition, a series of 5-methyl-N-(3-oxocyclohex-1-enyl) -isoxazole-3-carboxamides were synthesized and evaluated for anticonvulsant activity. These compounds were compared to the activity of the corresponding amino and aminomethyl enaminones. Additional investigation involved the synthesis and evaluation of a trifluoromethyl analog of the active isoxazole tert-butyl 4-(5-methisoxazol-3-yl-amino)-6-methyl-2-oxo-cyclohex-3-ene carboxylate (4f).
2-AMINO-5-SUBSTITUTED PYRIMIDINE INHIBITORS
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Page/Page column 103-104, (2010/11/29)
Compounds having the general structure (A) are provided. The compounds of the invention are capable of inhibiting kinases, such as members of the Src kinase family, Vegfr and various other specific receptor and non-receptor kinases. Formula (I):