34058-62-3Relevant articles and documents
Nickel-catalyzed aromatic C-H alkylation with secondary or tertiary alkyl-bromine bonds for the construction of indolones
Liu, Chao,Liu, Dong,Zhang, Wei,Zhou, Liangliang,Lei, Aiwen
, p. 6166 - 6169 (2013)
A nickel-catalyzed aromatic C-H alkylation with tertiary or secondary alkyl-Br bonds for the construction of indolones was demonstrated. Various functional groups were well tolerated. Moreover, the challenging secondary alkyl bromides were well introduced in this transformation. Radical trapping and photocatalysis conditions exhibited that it is most likely to be a radical process for this aromatic C-H alkylation.
Iron-Enhanced Reactivity of Radicals Enables C-H Tertiary Alkylations for Construction of Functionalized Quaternary Carbons
Yamane, Yu,Yoshinaga, Kohei,Sumimoto, Michinori,Nishikata, Takashi
, p. 1757 - 1762 (2019/02/14)
Iron is one of the most attractive catalysts, especially for aromatic C-H functionalizations. However, stoichiometric amounts of oxidants and strong carbanions are required, and C-H tertiary alkylation, especially with electron-deficient alkyl groups, is unexplored. In this paper, we describe the development of iron-catalyzed selective C-H tertiary alkylations with heteroaromatics, in which an iron salt acts as a single-electron source and enhances the reactivity of a tertiary alkyl radical generated from α-bromocarbonyl compounds. Our established methodology was demonstrated in the efficient synthesis of various quaternary carbon atoms under very simple conditions.
A tethering directing group strategy for ruthenium-catalyzed intramolecular alkene hydroarylation
Kilaru, Praveen,Acharya, Sunil P.,Zhao, Pinjing
supporting information, p. 924 - 927 (2018/02/07)
We report a new catalyst design for N-heterocycle synthesis that utilizes an alkene-tethered amide moiety as a directing group for aromatic C-H activation. This tethering directing group strategy is demonstrated in a ruthenium-catalyzed intramolecular alk