3406-76-6Relevant articles and documents
Access to Spirocyclic Benzothiophenones with Multiple Stereocenters via an Organocatalytic Cascade Reaction
Formánek, Bed?ich,Tauchman, Ji?í,Císa?ová, Ivana,Vesely, Jan
, p. 8510 - 8521 (2020/07/16)
The present report describes an organocatalytic cascade reaction between 2-alkylidene benzo[b]thiophenone derivatives and enones in the presence of the Cinchona alkaloid amine. Spirobenzothiophenonic cyclohexane derivatives containing three stereocenters were prepared via one-step synthesis in yields ranging from 88 to 96% and in enantioselectivities (enantiomeric excess (ee)) ranging from 85 to 97%, with diastereoselectivities of approximately 14/2/1. Therefore, this method provides an efficient route for the synthesis of a new class of optically active 2-spirobenzothiophenones.
Thioether compound, preparation method thereof, medical intermediate and application thereof
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Paragraph 0087-0094, (2020/08/27)
The invention relates to the technical field of chemical synthesis, and particularly discloses a thioether compound, a preparation method of the thioether compound, a medical intermediate and application of the medical intermediate, and the thioether compound is prepared from the following raw materials: a sulfoxide compound, a bromide and 1-butyl-3-methylimidazole trifluoromethanesulfonate. The thioether compound provided by the invention is reacted in ionic liquid 1-butyl-3-methylimidazole trifluoromethanesulfonate, a metal catalytic reaction is not needed, the problems of metal residues, organic solvent pollution and the like are fundamentally eliminated, and the thioether compound is particularly suitable for synthesis of some medicines and has relatively high economic applicability. The preparation method provided by the invention has the advantages of simple operation, high yield, high product purity, no need of metal catalysis in the whole reaction, mild reaction conditions andwide substrate range, solves the problem of easy generation of metal residues in the synthesized product due to use of transition metals for catalytic reaction in synthesis of thioether compounds in the prior art, and has a wide market prospect.
Sulfoxide Reduction/C(sp3)-S Metathesis Cascade in Ionic Liquid
Liu, Chenjing,Chen, Dengfeng,Fu, Yuanyuan,Wang, Fei,Luo, Jinyue,Huang, Shenlin
supporting information, p. 5701 - 5705 (2020/07/24)
A sulfoxide reduction/C-S bond metathesis cascade between sulfoxides and alkyl bromides has been developed to access high-value sulfides without the use of any catalysts or bases. In this cascade, classical Kornblum oxidation is employed to reduce sulfoxides with alkyl bromides in ionic liquid. This protocol features high functional tolerance, mild conditions, promising scalability, and sustainable solvents.