34074-22-1

Basic information

• Product Name: 2,6-Dichloro-4-iodophenol
• Synonyms: 2,6-Dichloro-4-iodophenol;Phenol, 2,6-dichloro-4-iodo-
• CAS NO: 34074-22-1
• Molecular Formula: C₆H₃Cl₂IO
• Molecular Weight: 288.89789
• Mol File: 34074-22-1.mol
• Article Data: 14

Chemical Properties

• Melting Point: 91-92 °C
• Boiling Point: 278.2±40.0 °C(Predicted)
• Appearance: /
• Density: 2.158±0.06 g/cm3(Predicted)
• Storage Temp.: under inert gas (nitrogen or Argon) at 2–8 °C
• PKA: 6.42±0.23(Predicted)
• CAS DataBase Reference: 2,6-Dichloro-4-iodophenol(CAS DataBase Reference)
• NIST Chemistry Reference: 2,6-Dichloro-4-iodophenol(34074-22-1)
• EPA Substance Registry System: 2,6-Dichloro-4-iodophenol(34074-22-1)

Safety Data

• Hazardous Substances Data: 34074-22-1(Hazardous Substances Data)

Usage

General Description

2,6-Dichloro-4-iodophenol is a chemical compound with the molecular formula C6H3Cl2IO. It is a white to off-white crystalline solid that is used in various applications, including as an intermediate in the synthesis of pharmaceuticals and agricultural chemicals. 2,6-Dichloro-4-iodophenol is known for its antimicrobial and antibacterial properties, making it a useful ingredient in disinfectants and antiseptics. It is also used in the manufacturing of dyes and pigments. 2,6-Dichloro-4-iodophenol is considered to be potentially harmful if ingested, inhaled, or absorbed through the skin and should be handled with caution and according to safety guidelines.

Upstream product

• 87-65-0 2,6-Dichlorophenol 
• 540-38-5 p-Iodophenol 
• 116130-33-7 2-chloro-4-iodophenol 

Downstream Products

• 946-31-6 2-chloro-4,6-dinitro-phenol 
• 586413-77-6 (3,5-dichloro-4-hydroxy-phenyl)-oxo-acetic acid methyl ester 
• 913171-32-1 [3-(2,6-dichloro-4-iodo-phenoxy)-propyl]-dimethyl-amine 
• 913172-12-0 [3-(2,6-dichloro-4-iodo-phenoxy)-propyl]-carbamic acid tert-butyl ester 
• 913171-87-6 (E)-3-[3,5-Dichloro-4-(3-dimethylamino-propoxy)-phenyl]-acrylic acid methyl ester 
• 913171-90-1 (E)-3-[3,5-Dichloro-4-(3-dimethylamino-propoxy)-phenyl]-acrylic acid 
• 913172-22-2 [3-(4-bromoethynyl-2,6-dichloro-phenoxy)-propyl]-carbamic acid tert-butyl ester 
• 913172-27-7 {3-[2,6-dichloro-4-(2-dimethylamino-ethyl)-phenoxy]-propyl}-carbamic acid tert-butyl ester 
• 913172-17-5 [3-(2,6-dichloro-4-trimethylsilanylethynyl-phenoxy)-propyl]-carbamic acid tert-butyl ester 
• 71742-42-2 1,3-dichloro-5-iodo-2-methoxybenzene 
• 1310726-01-2 1,3-dichloro-5-iodo-2-phenoxybenzene 
• 1218790-28-3 2-(3,5-dichloro-4-isopropoxyphenyl)-4,4,5,5-tetramethyl-1,3,2-dioxaborolane 

Relevant articles and documents

Iodine(III)-Mediated, Controlled Di- or Monoiodination of Phenols

An oxidative procedure for the electrophilic iodination of phenols was developed by using iodosylbenzene as a nontoxic iodine(III)-based oxidant and ammonium iodide as a cheap iodine atom source. A totally controlled monoiodination was achieved by buffering the reaction medium with K3PO4. This protocol proceeds with short reaction times, at mild temperatures, in an open flask, and generally with high yields. Gram-scale reactions, as well as the scope of this protocol, were explored with electron-rich and electron-poor phenols as well as heterocycles. Quantum chemistry calculations revealed PhII(OH)·NH3 to be the most plausible iodinating active species as a reactive "I+" synthon. In light of the relevance of the iodoarene moiety, we present herein a practical, efficient, and simple procedure with a broad functional group scope that allows access to the iodoarene core unit.

Ultrasound-promoted rapid and efficient iodination of aromatic and heteroaromatic compounds in the presence of iodine and hydrogen peroxide in water

A rapid and efficient ultrasound-promoted protocol for iodination of aromatic and heteroaromatic compounds, using molecular iodine in the presence of aqueous hydrogen peroxide in water without any cosolvent, has produced versatile iodinated organic molecules with potential application in organic synthesis and medicine in short reaction times and good to excellent yields. Copyright

Copper-catalyzed domino route to natural nostoclides and analogues: A total synthesis of nostoclides i and II

An original and convenient domino route to natural nostoclides I and II has been developed using a two-step sequence consisting of a copper-cat-alyzed tandem reaction associated with Suzuki cross-coupling. The methodology employed for this total synthesis appeared to be an interesting and suffi-ciently flexible tool to allow the synthesis of numer-ous analogues of these nostoclides.