3409-88-9

Basic information

• Product Name: N,N'-1,2-ethanediylbis(4-methoxybenzamide)
• Synonyms: N,N'-1,2-ethanediylbis(4-methoxybenzamide);N,N'-ethane-1,2-diylbis(4-methoxybenzamide)
• CAS NO: 3409-88-9
• Molecular Formula: C₁₈H₂₀N₂O₄
• Molecular Weight: 328.3624
• Mol File: 3409-88-9.mol
• Article Data: 3

Chemical Properties

• Appearance: /
• CAS DataBase Reference: N,N'-1,2-ethanediylbis(4-methoxybenzamide)(CAS DataBase Reference)
• NIST Chemistry Reference: N,N'-1,2-ethanediylbis(4-methoxybenzamide)(3409-88-9)
• EPA Substance Registry System: N,N'-1,2-ethanediylbis(4-methoxybenzamide)(3409-88-9)

Safety Data

• Hazardous Substances Data: 3409-88-9(Hazardous Substances Data)

Upstream product

• 94-30-4 ethyl 4-methoxybenzoate 
• 107-15-3 ethylenediamine 
• 100-07-2 4-methoxy-benzoyl chloride 

Downstream Products

• 121-98-2 methyl 4-methoxybenzoate 
• 3852-14-0 N,N-methylenediacetamide 
• 874-90-8 4-methoxybenzonitrile 

Relevant articles and documents

One-Pot Anodic Conversion of Symmetrical Bisamides of Ethylene Diamine to Unsymmetrical gem-Bisamides of Methylene Diamine

Symmetrical bisamides of ethylene diamine of type ArCONHCH2CH2NHCOAr undergo anodic C-C bond cleavage in acetonitrile-LiClO4 under controlled-potential electrolysis. The electrogenerated carbocation intermediates react with the solvent acetonitrile to afford unsymmetrical gem-bisamides of type ArCONHCH2NHCOMe in a one-pot reaction. The yields of the latter products are moderate (up to 60%). Other minor products involve two symmetrical gem-bisamides of type ArCONHCH2NHCOAr and MeCONHCH2NHCOMe and fragmentation products (e.g., ArCONHCHO, ArCONH2, and ArCN).

ANTIMICROBIAL COMPOUNDS

The invention provides compounds for use in treating microbial infection in an animal. Example compounds include Pyridin-3-ylmethyl (4-((2-aminophenyl)- carbamoyl)benzyl)carbamate ("Entinostat"). The compounds can act via induction of the innate antimicrobial peptide defense system, and stimulation of autophagy.