34097-16-0

Basic information

• Product Name: CLOCORTOLONE PIVALATE (200 MG)
• Synonyms: 9-chloro-6α-fluoro-11β,21-dihydroxy-16α-methylpregna-1,4-diene-3;CLOCORTOLONE PIVALATE (200 MG);9-chloro-6alpha-fluoro-11beta,21-dihydroxy-16alpha-methylpregna-1,4-diene-3,20-dione 21-pivalate;clocortolone pivalate;9-Chloro-6α,11β-dihydroxy-21-pivaloyloxy-16α-methylpregna-1,4-diene-3,20-dione;SH-863;(6α,11β,16α)-9-Chloro-21-(2,2-diMethyl-1-oxopropoxy)-6-fluoro-11-hydroxy-16-Methypregna-1,4-diene-3,20-dione;9-Chloro-6α-fluoro-11β,21-dihydroxy-16α-Methylpregna-1,4-diene-3,20-dione 21-Pivalate
• CAS NO: 34097-16-0
• Molecular Formula: C₂₇H₃₆ClFO₅
• Molecular Weight: 495.0231432
• EINECS: 251-826-5
• Product Categories: Intermediates & Fine Chemicals;Pharmaceuticals;Steroids
• Mol File: 34097-16-0.mol
• Article Data: 0

Chemical Properties

• Boiling Point: 597.979 °C at 760 mmHg
• Flash Point: 315.447 °C
• Appearance: /
• Density: 1.245 g/cm³
• Vapor Pressure: 8.58E-17mmHg at 25°C
• Refractive Index: 1.551
• Storage Temp.: Refrigerator, under inert atmosphere
• Solubility: Chloroform (Slightly), DMSO (Slightly), Ethanol (Slightly), Methanol (Slightly)
• PKA: 13.04±0.70(Predicted)
• CAS DataBase Reference: CLOCORTOLONE PIVALATE (200 MG)(CAS DataBase Reference)
• NIST Chemistry Reference: CLOCORTOLONE PIVALATE (200 MG)(34097-16-0)
• EPA Substance Registry System: CLOCORTOLONE PIVALATE (200 MG)(34097-16-0)

Safety Data

• Hazardous Substances Data: 34097-16-0(Hazardous Substances Data)

Usage

Description

Clocortolone Pivalate (200 MG) is a corticosteroid medication, chemically known as 9-chloro-21-(2,2-dimethyl-1-oxopropoxy)-6α-fluoro-11β-hydroxy-16α-methylpregna-1,4-diene-3,20-dione. It is a derivative of clocortolone, with the addition of a 21-O-pivalate ester. This modification results in improved anti-inflammatory and antipruritic properties, making it a valuable pharmaceutical compound for treating various skin conditions.

Uses

Used in Pharmaceutical Industry:
Clocortolone Pivalate (200 MG) is used as a topical medication for the treatment of atopic dermatitis, a common inflammatory skin condition characterized by itching, redness, and swelling. Its potent anti-inflammatory and antipruritic effects help alleviate the symptoms and improve the overall skin condition.
Additionally, Clocortolone Pivalate (200 MG) is used for the relief of other inflammatory and pruritic skin disorders, such as eczema, psoriasis, and contact dermatitis. Its effectiveness in reducing inflammation and itching makes it a preferred choice for managing these conditions.
Brand Name:
The brand name for Clocortolone Pivalate (200 MG) is Cloderm, which is manufactured and distributed by Healthpoint.

InChI:InChI=1/C27H36ClFO5/c1-14-9-16-17-11-19(29)18-10-15(30)7-8-26(18,6)27(17,28)21(32)12-25(16,5)22(14)20(31)13-34-23(33)24(2,3)4/h7-8,10,14,16-17,19,21-22,32H,9,11-13H2,1-6H3/t14-,16+,17+,19+,21+,22-,25+,26+,27+/m1/s1