341-24-2

Basic information

• Product Name: 7-FLUORO INDAZOLE
• Synonyms: 7-FLUORO INDAZOLE;7-Fluoro-1H-indazole;1H-Indazole, 7-fluoro-;7-fluoro-1(2)H-indazole
• CAS NO: 341-24-2
• Molecular Formula: C₇H₅FN₂
• Molecular Weight: 136.1264032
• Mol File: 341-24-2.mol
• Article Data: 4

Chemical Properties

• Melting Point: 120 °C (decomp)
• Boiling Point: 274.9 °C at 760 mmHg
• Flash Point: 120.1 °C
• Appearance: /
• Density: 1.37 g/cm³
• Vapor Pressure: 0.00883mmHg at 25°C
• Refractive Index: 1.658
• Storage Temp.: 2-8°C
• PKA: 12.10±0.40(Predicted)
• CAS DataBase Reference: 7-FLUORO INDAZOLE(CAS DataBase Reference)
• NIST Chemistry Reference: 7-FLUORO INDAZOLE(341-24-2)
• EPA Substance Registry System: 7-FLUORO INDAZOLE(341-24-2)

Safety Data

• Hazard Codes: Xn
• Statements: 22-36/37/38
• Safety Statements: 26
• Hazardous Substances Data: 341-24-2(Hazardous Substances Data)

Usage

General Description

7-Fluoro indazole is a chemical compound with the molecular formula C7H6FN3. It is a fluorinated derivative of indazole, a five-membered aromatic ring with two nitrogen atoms. 7-Fluoro indazole is a building block in the synthesis of pharmaceuticals and agrochemicals, and it is also used as a research tool in medicinal chemistry and drug discovery. It exhibits potential biological activity and has been studied for its potential applications in the treatment of various diseases and conditions. Additionally, 7-Fluoro indazole has been investigated for its potential as a ligand in coordination chemistry and as a component in the design of new materials.

InChI:InChI=1/C7H5FN2/c8-6-3-1-2-5-4-9-10-7(5)6/h1-4H,(H,9,10)

Upstream product

• 394-50-3 3-fluorosalicylaldehyde 
• 18355-80-1 2,3-difluoroacetophenone 
• 2646-91-5 2,3-difluorobenzaldehyde 

Downstream Products

• 1010103-16-8 7-fluoro-4-nitro-1H-indazole 
• 1105175-05-0 7-fluoro-5-nitro-1H-indazole 

Relevant articles and documents

Synthesis, antifungal activity and qsar of novel pyrazole amides as succinate dehydrogenase inhibitors

We design and synthesize a series of novel pyrazole amides based on the commercialized fungicides and our previous work. The antifungal activity was tested in vitro by mycelial growth inhibition assay. The results show that all the compounds are of antifungal activities against the tested fungi at different levels. Among them, N-(2-(7-bromo-5-chloro-1H-indazol-1-yl)phenyl)-3-(difluoromethyl)-1-methyl-1H-pyrazole-4-carboxamide (Vk) exhibited higher antifungal activity than boscalid against two fungi. Molecular docking study revealed that the carbonyl oxygen atom of Vk forms two hydrogen bonds toward the hydroxyl hydrogens of TYR58 and TRP173.

HETEROCYCLE DERIVATIVE HAVING PGD2 RECEPTOR ANTAGONIST ACTIVITY

The present invention is related to a compound represented by formula (I), wherein X1, X2, X3, X4, X5, R5, R6, R7, R8, n, p, q, ring A and ring B are as described in the specification, or a