341529-07-5 Usage
General Description
1-(Trimethylsilyldifluoromethyl)-1H-imidazole is a chemical compound used in organic synthesis and pharmaceutical research. It is a substituted imidazole derivative with a trimethylsilyl group and a difluoromethyl group attached to the nitrogen atom. 1-(TRIMETHYLSILYLDIFLUOROMETHYL)-1H-IMIDAZOLE is an important building block in the preparation of various pharmaceuticals and agrochemicals. It has applications in the synthesis of antiviral and antifungal agents, as well as in the development of new materials and chemical processes. Due to its unique structure and reactivity, 1-(trimethylsilyldifluoromethyl)-1H-imidazole has garnered interest in the scientific community for its potential in drug discovery and medicinal chemistry.
Check Digit Verification of cas no
The CAS Registry Mumber 341529-07-5 includes 9 digits separated into 3 groups by hyphens. The first part of the number,starting from the left, has 6 digits, 3,4,1,5,2 and 9 respectively; the second part has 2 digits, 0 and 7 respectively.
Calculate Digit Verification of CAS Registry Number 341529-07:
(8*3)+(7*4)+(6*1)+(5*5)+(4*2)+(3*9)+(2*0)+(1*7)=125
125 % 10 = 5
So 341529-07-5 is a valid CAS Registry Number.
InChI:InChI=1/C7H12F2N2Si/c1-12(2,3)7(8,9)11-5-4-10-6-11/h4-6H,1-3H3
341529-07-5Relevant articles and documents
Heteroaryl-N-difluoromethyltrimethylsilanes - Versatile sources of heteroaryl-N-difluoromethyl anions in reactions with carbonyl compounds
Bissky,Staninets,Kolomeitsev,R?schenthaler
, p. 374 - 378 (2007/10/03)
An efficient procedure for synthesizing heteroaryl-N-difluoromethyltrimethylsilanes - new nucleophilic difluoromethylene synthons - from easily available N-bromodifluoromethylated heterocycles, chlorotrimethylsilane and aluminium powder in triglyme or N-methylpyrrolidinone on a preparative scale in 71-75% isolated yield is described. Heteroaryl-N-difluoromethyltrimethylsilanes and benzaldehyde react under fluoride ion catalysis to give 1-(1,1-difluor-2-hydroxy-2-phenyl-ethyl)heteroaryls, whereas for anionic heteroaryl-N-difluoromethylation of cyclohexanone a stoichiometrical mixture of heteroaryl-N-difluoromethyltrimethylsilanes and tetramethylammonium fluoride has to be used.
