34162-79-3Relevant articles and documents
Oxiranylidene-2,2-bis(phosphonate): Unambiguous Synthesis, Hydrolysis to 1,2-Dihydroxyethylidene-1,1-bis(phosphonate), and Identification as the Primary Product from Mild Na2WO4/H2O2 Oxidation of Ethylidene-1,1-bis(phosphonate)
Duncan, Gregory D.,Li, Zeng-Min,Khare, Anil B.,McKenna, Charles E.
, p. 7080 - 7081 (1995)
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Challenging synthesis of bisphosphonate derivatives with reduced steric hindrance
Chiminazzo, Andrea,Sperni, Laura,Fabris, Fabrizio,Scarso, Alessandro
supporting information, (2021/04/12)
An alternative approach is reported for the synthesis of methyl ester protected bisphosphonate building blocks, such as methylene bisphosphonate, vinylidenebisphosphonate and aryl substituted prochiral vinylidenebisphosphonates, that cannot be obtained directly from dimethyl phosphite and dichloromethane.
Bisphosphonate-Prodrugs
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Paragraph 0051; 0056, (2014/03/24)
The present invention relates to a prodrug, comprising a pharmaceutically and/or diagnostically active compound, and one or more bisphosphonate groups, to a process for producing such a prodrug, and to a pharmaceutical composition comprising said prodrug, to be used for the treatment of bone-related disorders such as bone cancer.
ETUDE PAR RMN DES REACTIONS D'ADDITION DES SPIROPHOSPHORANES A LIAISON P-H SUR LE TETRA ETHYLE ET LE TETRA METHYLE ETHYLIDENE BIS PHOSPHONATE
Burgada, Ramon,Bailly, Theodorine
, p. 125 - 132 (2007/10/02)
The spirophosphoranes 1 to 4,6 and 7 bearing a P-H bond have been condensed with tetraethyl (z) or tetra methyl (x) ethenylidene bis phosphonate by a Michael type addition reaction.The resulting compounds: Spirophosphoranes-bis phosphonates 1x, 3x, 4x, 5x, 6x, 7x and 2z, 4z, 5z, 7z havd been studied by NMR 1H, 31P and 13C.With the spirophosphorane 7 that contain 90percent of its tricoordinated form 7' the formation of an intermediate 7ax or 7az has been observed: 7ax or 7az give rise to a slow transposition at 20 deg C or a fast rearrangement at 60 deg C into phosphorane 7x or 7z.Key words: Ethenylidene bis phosphonate, spirophosphorane, phosphorane-bis phosphonate, stereomutation, tautomeric equilibrium PIII-PV, diastereotopy.