34176-17-5

Basic information

• Product Name: 1-(4-(benzyloxy)-2,5-dihydroxyphenyl)ethan-1-one
• Synonyms: 1-(4-(benzyloxy)-2,5-dihydroxyphenyl)ethan-1-one
• CAS NO: 34176-17-5
• Molecular Weight: 258.274
• Mol File: 34176-17-5.mol
• Article Data: 6

Chemical Properties

• Melting Point: 160–162°C
• CAS DataBase Reference: 1-(4-(benzyloxy)-2,5-dihydroxyphenyl)ethan-1-one(CAS DataBase Reference)
• NIST Chemistry Reference: 1-(4-(benzyloxy)-2,5-dihydroxyphenyl)ethan-1-one(34176-17-5)
• EPA Substance Registry System: 1-(4-(benzyloxy)-2,5-dihydroxyphenyl)ethan-1-one(34176-17-5)

Safety Data

• Hazardous Substances Data: 34176-17-5(Hazardous Substances Data)

Usage

Preparation

Preparation by reaction of benzyl halide with 2,4,5-tri-hydroxyacetophenone in the presence of potassium carbonate in refluxing acetone (62%).

Upstream product

• 100-39-0 benzyl bromide 
• 100-44-7 benzyl chloride 
• 89-84-9 2',4'-dihydroxy-4-acetophenone 
• 29682-12-0 1-[4-(benzyloxy)-2-hydroxyphenyl]ethanone 
• 34176-18-6 1-(4-(benzyloxy)-2-hydroxy-5-methoxyphenyl)ethan-1-one 
• 7298-21-7 1-(2,4-dihydroxy-5-methoxyphenyl)ethan-1-one 
• 1818-28-6 2',4',5'-trimethoxyacetophenone 
• 1818-27-5 1-(2,4,5-trihydroxyphenyl)ethanone 

Downstream Products

• 7298-39-7 4',5'-bis(benzyloxy)-2'-hydroxyacetophenone 
• 7298-21-7 1-(2,4-dihydroxy-5-methoxyphenyl)ethan-1-one 
• 34176-18-6 1-(4-(benzyloxy)-2-hydroxy-5-methoxyphenyl)ethan-1-one 
• 74693-72-4 2',4',5'-tribenzyloxy-3,4-dimethoxychalkone epoxide 
• 74693-71-3 2',4',5'-tribenzyloxy-3,4-dimethoxychalkone 
• 74693-70-2 2'-hydroxy-4',5'-dibenzyloxy-3,4-dimethoxychalkone 
• 58511-89-0 6,7-dimethoxy-4H-benzopyran-4-one 
• 209982-69-4 7-Benzyloxy-2-(3-benzyloxy-4-methoxy-phenyl)-3,6-dimethoxy-chromen-4-one 
• 209982-68-3 7-Benzyloxy-2-(3-benzyloxy-4-methoxy-phenyl)-3-hydroxy-6-methoxy-chromen-4-one 
• 82298-12-2 2'-Hydroxy-3,4'-dibenzyloxy-4,5'-dimethoxychalkone 

Relevant articles and documents

Structure Optimization of Gatastatin for the Development of γ-Tubulin-Specific Inhibitor

Gatastatin (O7-benzyl glaziovianin A) is a γ-tubulin-specific inhibitor that is used to investigate γ-tubulin function in cells. We have previously reported that the unsubstituted phenyl ring of the O7-benzyl group in gatastatin is important for γ-tubulin

2-OXO-5H-CHROMENO[4,3-B]PYRIDINES FOR USE IN THE TREATMENT OF HEPATITIS B

The present invention discloses compounds according to Formula (I), wherein R1, R2a, R2b, R3, R4, and R5 are as defined herein. The present invention relates to compounds, methods for their production, pharmaceutical compositions comprising the same, and methods of treatment using the same, for the prophylaxis and/or treatment of diseases involving hepatitis B by administering the compound of the invention.

Structure-activity requirements for flavone cytotoxicity and binding to tubulin

A series of 79 flavones related to centaureidin (3,6,4'-trimethoxy- 5,7,3'-trihydroxyflavone, 1) was screened for cytotoxicity in the NCI in vitro 60-cell line human tumor screen. The resulting cytotoxicity profiles of these flavones were compared for deg