342416-99-3

Basic information

• Product Name: 6-CHLORO-4-O-TOLYL-NICOTINIC ACID
• Synonyms: 6-CHLORO-4-O-TOLYL-NICOTINIC ACID;3-PYRIDINECARBOXYLIC ACID, 6-CHLORO-4-(2-METHYLPHENYL)-
• CAS NO: 342416-99-3
• Molecular Formula: C₁₃H₁₀ClNO₂
• Molecular Weight: 247.677
• Mol File: 342416-99-3.mol
• Article Data: 6

Chemical Properties

• Appearance: /
• CAS DataBase Reference: 6-CHLORO-4-O-TOLYL-NICOTINIC ACID(CAS DataBase Reference)
• NIST Chemistry Reference: 6-CHLORO-4-O-TOLYL-NICOTINIC ACID(342416-99-3)
• EPA Substance Registry System: 6-CHLORO-4-O-TOLYL-NICOTINIC ACID(342416-99-3)

Safety Data

• Hazardous Substances Data: 342416-99-3(Hazardous Substances Data)

Upstream product

• 5326-23-8 6-Chloro-3-pyridinecarboxylic acid 
• 33872-80-9 o-tolyl magnesium chloride 
• 19513-05-4 manganese(III) triacetate dihydrate 

Downstream Products

• 290297-24-4 6-(4-methyl-piperazin-1-yl)-4-o-tolylpyridin-3-yl-amine 
• 1431216-61-3 1-(5-(2-(3,5-bis(trifluoromethyl)phenyl)-N,2-dimethylpropanamido)-4-(o-tolyl)pyridin-2-yl)-4-methylpiperazine 1,4-dioxide 
• 342417-02-1 [6-(4-methylpiperazin-1-yl)-4-(o-tolyl)pyridin-3-yl]carbamic acid methyl ester 
• 342417-01-0 4-(2-methylphenyl)-6-(4-methylpiperazinyl)-3-pyridinecarboxamide 
• 342417-00-9 6-chloro-4-(o-tolyl)nicotinamide 
• 290297-26-6 netupitant 
• 290297-25-5 methyl-[6-(4-methyl-piperazin-1-yl)-4-o-tolyl-pyridin-3-yl]-amine 
• 1431216-68-0 4-(5-{2-[3,5-bis(trifluoromethyl)phenyl]-N,2-dimethylpropanamido}-4-(o-tolyl)pyridin-2-yl)-1-methyl-1-{[bis(tert-butoxy)phosphoryl]oxymethyl}piperazin-1-ium 
• 1431216-59-9 4-(5-(2-(3,5-bis(trifluoromethyl)phenyl)-N,2-dimethylpropanamido)-4-(o-tolyl)pyridin-2-yl)-1-methyl-1-((phosphonooxy)methyl)piperazin-1-ium 

Relevant articles and documents

4-(5-(2-(3,5-bis(trifluoromethyl)phenyl)-N,2-dimethylpropanamido)-4-(o-tolyl)pyridin-2-yl)-1-methyl-1-((phosphonooxy)methyl)piperazin-1-ium as a neurokinin receptor modulator

Compounds and methods for the prevention and/or treatment of diseases which are pathophysiologically mediated by the neurokinin (NK1) receptor, based on 4-(5-(2-(3,5-bis(trifluoromethyl)phenyl)-N,2-dimethylpropanamido)-4-(o-tolyl)3yridine-2-yl)-1-methyl-1-((phosphonooxy)methyl)piperazin-1-ium and pharmaceutically acceptable salts thereof.

Substituted 4-phenyl pyridines having anti-emetic effect

Disclosed are compounds, compositions and methods for the prevention and/or treatment of diseases which are pathophysiologically mediated by the neurokinin (NK1) receptor. The compounds have the general formula (I):

Process for the preparation of pyridine derivatives

A process is described for preparing certain 4-alkyl- or 4-aryl-pyridine derivatives.