3425-61-4Relevant articles and documents
Recombination of 1,1-dimethylpropyl peroxy radicals in polar solvents
Denisova,Shuvalov
, p. 22 - 25 (2016)
The kinetics of 1,1-dimethylpropyl peroxy radicals recombination in polar solvents - water, methanol, and their mixtures - was studied by EPR spectroscopy in combination with the stopped-flow method, and the rate constants of this reaction were determined. Peroxyl radicals were generated by mixing solutions of Ce4+ sulfate and 1,1-dimethylpropyl hydroperoxide. The observed EPR signal of the peroxyl radical is a singlet with a g-factor of 2.015 ± 0.001, and a line width of ΔH = (1.36 ± 0.02) × 10-3 T for methanol and ΔH = (9.7 ± 0.2) × 10-4 T for water. The measured rate constants of (CH3)2C(O2 ·)CH2CH3 radical recombination at 298 K are 2k t = (3.9 ± 0.4) × 104 L mol-1 s-1 for water and 2k t = (5.2 ± 0.5) × 103 L mol-1 s-1 for methanol. A linear relationship between ln(2kt ) and the Kirkwood function (?-1)/(2? + 1), where e is the dielectric constant of the medium, has been established, indicating an important role of nonspecific solvation in the recombination of tertiary peroxyl radicals.
ONLINE CONTINUOUS FLOW PROCESS FOR THE SYNTHESIS OF ORGANIC PEROXIDES USING HYDROGEN PEROXIDE AS RAW MATERIAL
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Paragraph 0290; 0293, (2020/06/29)
An online continuous flow production process for directly preparing organic peroxides by using hydrogen peroxide as a raw material. This production process uses hydrogen peroxide, catalyst, and an oxidation substrate as a raw material. Substrate will be turned to designated peroxides sequentially through oxidation and workup. This process is performed in a plug-and-produce integrated continuous flow reactor, and the raw materials are continuously fed to the reactor. So, specified peroxide can be continuously obtained at the outlet of the plug-and-produce integrated continuous flow reactor.
New route for conversion of camptothecin to 7-ethylcamptothecin and 7-propylcamptothecin
Wang, Xin,Wu, Xiaojing,Cheng, Ning,Zhao, Huiqing,Gu, Zhihong,Shen, Xiang
, p. 519 - 523 (2007/10/03)
In this article, a new route for conversion of camptothecin to 7-ethylcamptothecin and 7-propylcamptothecin is described. Compared with previous reports, the reaction time of the new synthetic route was greatly shortened to 30 min, and the products were obtained in high yield. Copyright Taylor & Francis Group, LLC.
