34250-61-8Relevant articles and documents
Facile synthesis of bioactive 4H-[1,4]-benzothiazines under solvent free conditions
Kalwania,Chomal,Choudhary, Savita
, p. 5133 - 5136 (2012/06/18)
An efficient method for synthesis of 4H-[1,4]-benzothiazines under solvent free conditions has been developed. The oxidative condensation of 2-aminobenzenethiols with β-diketones/β-ketoesters in presence of catalytic amount of hydrazine hydrate yields the 4H-[1,4]-benzothiazines. The reaction is accelerated by microwave irradiation under solvent free conditions in presence of an energy transfer agent DMF to get the product in high yield. The 2-aminobenzenethiazole required for the synthesis of 4H-[1,4]-benzothiazines are also obtained by a new method instead of presently used time consuming and low yielding method. The structure of the synthesized compounds has been characterized by IR, NMR, mass spectral studies and elemental analysis.
Microwave-induced one pot synthesis and biological screening of 8-substituted-2,5-dihydro-1,5-benzothiazepin-2-spiro-3'-3'H-indol-2'-(1'H)-ones
Dandia, Anshu,Upreti, Mani,Rani, Babita,Pant, Umesh C.
, p. 3348 - 3355 (2007/10/03)
A convenient method for the synthesis of 8-substituted-2,5-dihydro-1,5-benzothiazepin-2-spiro-3'-3'H-indol-2'-(1'H)-ones, by one pot procedure under microwave irradiation, using ethylene glycol as energy transfer medium, is described. Results are compared
PYRIMIDO-BENZOTHIAZINES
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, (2008/06/13)
This invention relates to novel pyrimido-benzothiazine derivative compounds. The compounds of the present invention inhibit the action of the lipoxygenase enzyme and are useful in the treatment or alleviation of inflammatory diseases, allergy and cardiovascular diseases in mammals. this invention also relates to pharmaceutical compositions comprising such compounds.