34259-86-4

Basic information

• Product Name: 1-(phenylsulfonyl)piperidin-4-one
• Synonyms: 1-(phenylsulfonyl)piperidin-4-one;1-phenylsulfonyl-4-piperidinone;1-phenylsulfonyl-4-piperidone;ghl.PD_Mitscher_leg0.872
• CAS NO: 34259-86-4
• Molecular Formula: C₁₁H₁₃NO₃S
• Molecular Weight: 239.29082
• Mol File: 34259-86-4.mol
• Article Data: 16

Chemical Properties

• Appearance: /
• CAS DataBase Reference: 1-(phenylsulfonyl)piperidin-4-one(CAS DataBase Reference)
• NIST Chemistry Reference: 1-(phenylsulfonyl)piperidin-4-one(34259-86-4)
• EPA Substance Registry System: 1-(phenylsulfonyl)piperidin-4-one(34259-86-4)

Safety Data

• Hazardous Substances Data: 34259-86-4(Hazardous Substances Data)

Upstream product

• 177-11-7 4,4-ethylenedioxy-piperidine 
• 98-09-9 benzenesulfonyl chloride 
• 41661-47-6 piperidin-4-one 
• 108-98-5 thiophenol 
• 609785-04-8 8-(phenylsulfonyl)-1,4-dioxa-8-azaspiro[4.5]decane 
• 41979-39-9 4-piperidone hydrochloride 

Downstream Products

• 267666-13-7 1-benzenesulfonyl-4,4-dimethoxy-piperidine 
• 919491-03-5 1-benzenesulfonyl-4-trimethylsilanyloxy-1,2,3,6-tetrahydropyridine 
• 919491-04-6 1-benzenesulfonyl-3-bromopiperidine-4-one 
• 919491-06-8 1-benzenesulfonyl 5-bromo-4-trifluromethanesulfonyloxy-1,2,3,6-tetrahydropyridine 
• 919491-09-1 1-benzenesulfonyl-5-bromo-4-(1-tert-butoxy-7a-methyl-2,3,3a,6,7,7a-hexahydro-1H-inden-5-yl)-1,2,3,6-tetrahydro-pyridine 
• 919491-23-9 1-benzenesulfonyl-5-bromo-4-(1-tert-butoxy-7a-methyl-2,3,3a,6,7,7a-hexahydro-1H-inden-5-yl)-1,2,3,6-tetrahydro-pyridine 
• 919491-12-6 (E)-(1''S,3a''R,7a''S)-tert-butyl 3-[1'-benzenesulfonyl-4'-(1''-tert-butoxy-7a''-methyl-2'',3'',3a'',6'',7'',7a''-hexahydro-1''H-indene-5''-yl)-1',2',5',6'-tetrahydropyridine-3'-yl]acrylate 
• 919491-14-8 (E)-(1''S,3a''S,7a''S)-tert-butyl 3-[1'-benzenesulfonyl-4'-(1''-tert-butoxy-7a''-methyl-2'',3'',3a'',6'',7'',7a''-hexahydro-1''H-indene-5''-yl)-1',2',5',6'-tetrahydropyridine-3'-yl]acrylate 
• 196882-97-0 4-methoxy-1-(phenylsulfonyl)-1,2,3,6-tetrahydropyridine 
• 196882-99-2 2,5-bis-benzenesulfonyl-8-hydroxy-7-methoxy-2,3,4,5-tetrahydro-1H-pyrido[4,3-b]indole 
• 267666-53-5 5-benzenesulfonyl-7-methoxy-5H-pyrido[4,3-b]indole 
• 267666-59-1 5-benzenesulfonyl-7-methoxy-5H-pyrido[4,3-b]indole 2-oxide 
• 267666-68-2 5-benzenesulfonyl-1-chloro-7-methoxy-5H-pyrido[4,3-b]indole 

Relevant articles and documents

THERAPEUTICS TARGETING MUTANT ADENOMATOUS POLYPOSIS COLI (APC) FOR THE TREATMENT OF CANCER

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Sulfonamide Synthesis through Electrochemical Oxidative Coupling of Amines and Thiols

Sulfonamides are key motifs in pharmaceuticals and agrochemicals, spurring the continuous development of novel and efficient synthetic methods to access these functional groups. Herein, we report an environmentally benign electrochemical method which enables the oxidative coupling between thiols and amines, two readily available and inexpensive commodity chemicals. The transformation is completely driven by electricity, does not require any sacrificial reagent or additional catalysts and can be carried out in only 5 min. Hydrogen is formed as a benign byproduct at the counter electrode. Owing to the mild reaction conditions, the reaction displays a broad substrate scope and functional group compatibility.

THERAPEUTICS TARGETING TRUNCATED ADENOMATOUS POLYPOSIS COLI (APC) PROTEINS

The described invention provides small molecule anti-cancer compounds that selectively target and inhibit measurable biological activity of truncated APC proteins, an immortalized Human Colonic Epithelial Cell (HCEC) model, and pharmaceutical compositions comprising at least one of the small molecule anti-cancer compounds and a pharmaceutically acceptable carrier.