34262-64-1 Usage
Biological Activity
8,11,14-eicosatriynoic acid, as an inhibitor of prostaglandin, leukotriene biosynthesis, and arachidonic acid induced platelet aggregation, blocks human 12-lipoxygenase (12-lo), cyclooxygenase (cox), and 5-lipoxygenase (5-lo) with ic50 values of 0.46 μm, 14 μm, and 25 μm, respectively. also, it inhibits the actions of slow-reacting substance of anaphylaxis with an ic50 value of 10 μm [1,2].lipoxygenases are found widely in fungi, plants, and animals in high levels. 12-lo is involved in a number of significant disease states and may play a role in oxidative glutamate toxicity. cox enzymes play elaborate roles in human physiology and pathology, involving neuronal, immune, renal, cardiovascular, gastrointestinal, and reproductive systems. cox enzymes are blocked by aspirin and a wide variety of other non-steroidal anti-inflammatory drugs, which makes them important clinically [3]. 5-lo is involved in cancer pathobiology. it is expressed by a variety of cancer cells including colon, lung, breast, and prostate and promotes cancer cell growth and neo-angiogenesis.
references
[1]. goetz, j., sprecher, h., cornwell, d., & panganamala, r. inhibition of prostaglandin biosynthesis by triynoic acids. prostaglandins. 1976; 12(2): 187-192. [2]. sun, f., mcguire, j., morton, d., pike, j., sprecher, h., & kunau, w. inhibition of platelet arachidonic acid 12-lipoxygenase by acetylenic acid compounds. prostaglandins. 1981; 21(2): 333-343. [3]. fitzpatrick, f. cyclooxygenase enzymes: regulation and function. current pharmaceutical design. 2004; 10(6): 577-588.
Check Digit Verification of cas no
The CAS Registry Mumber 34262-64-1 includes 8 digits separated into 3 groups by hyphens. The first part of the number,starting from the left, has 5 digits, 3,4,2,6 and 2 respectively; the second part has 2 digits, 6 and 4 respectively.
Calculate Digit Verification of CAS Registry Number 34262-64:
(7*3)+(6*4)+(5*2)+(4*6)+(3*2)+(2*6)+(1*4)=101
101 % 10 = 1
So 34262-64-1 is a valid CAS Registry Number.
34262-64-1Relevant articles and documents
A novel synthesis of (8Z,11Z,14Z)-8,11,14-eicosatrienoic (dihomo-γ-linoleic) acid and its 19-substituted analogue
Groza,Ivanov,Myagkova
, p. 401 - 404 (2007/10/03)
The total synthesis of dihomo-γ-linoleic acid and (8Z,11Z,14Z)-19-methyl-8,11,14-eicosatrienoic acid was accomplished using organometallic complexes of copper (I) in the cross-coupling reaction of propargyl synthones with terminal acetylenic reagents.
