342631-41-8

Basic information

• Product Name: Tenofovir Related Compound 1
• Synonyms: Tenofovir Related Compound 1;diphenyl (R)-(((1-(6-amino-9H-purin-9-yl)propan-2-yl)oxy)methyl)phosphonate;Tenofovir Impurity 29;Tenofovir Alafenamide Impurity 1;Tenofovir Alafenamide Impurity A;TAF Impurity A;6-amido-9-[(2R)-2-(diphenyl phosphoryl methoxy)Propyl]purine
• CAS NO: 342631-41-8
• Molecular Formula: C21H22N5O4P
• Molecular Weight: 439.404241
• Mol File: 342631-41-8.mol
• Article Data: 7

Chemical Properties

• Boiling Point: 636.3±65.0 °C(Predicted)
• Appearance: /
• Density: 1.39±0.1 g/cm3(Predicted)
• PKA: 4.21±0.10(Predicted)
• CAS DataBase Reference: Tenofovir Related Compound 1(CAS DataBase Reference)
• NIST Chemistry Reference: Tenofovir Related Compound 1(342631-41-8)
• EPA Substance Registry System: Tenofovir Related Compound 1(342631-41-8)

Safety Data

• Hazardous Substances Data: 342631-41-8(Hazardous Substances Data)

Usage

Uses

(R)-Diphenyl (((1-(6-amino-9H-purin-9-yl)propan-2-yl)oxy)methyl)phosphonate is a reagent for the synthesis of amidate prodrugs of PMEA and PMPA. Also functions as a reagent in the preparation of tenofovir alafenamide fumarate impurity.

Upstream product

• 379270-35-6 ((((R)-1-(6-amino-9H-purin-9-yl)propan-2-yl)oxy)methyl)phosphoric acid monophenyl ester 
• 108-95-2 phenol 
• 147127-20-6 tenofovir 

Downstream Products

• 180587-75-1 (R)-diethyl (((1-(6-amino-9H-purin-9-yl)propan-2-yl)oxy)methyl)phosphonate 
• 201341-05-1 tenofovir disoproxil 

Relevant articles and documents

Preparation method of high-purity tenofovir alafenamide impurity TAF-Y

The invention discloses a preparation method of a high-purity tenofovir alafenamide impurity TAF-Y. The preparation method comprises the following steps of performing chlorination on 9-[(R)-2-[[(phenoxyl phosphinyl)methoxyl]propyl]]adenine (TAF-M1), so as

A key intermediate for the preparation of fumaric acid for fuwei ira phenol amine (by machine translation)

The invention the invention belongs to the field of drug synthesis, relates to a pharmaceutical intermediates, in particular to a method for the preparation of a key intermediate in the fumaric acid for fuwei ira phenol amine. The present invention provid

Preparation method of amino phosphate ester derivatives and preparation method of intermediates and intermediates characterized in that at 0 DEG C -100 DEG C and in a solvent, the compound represented by the general formula (II) is subjected to an amino deprotection reaction in the presence of an alkaline reagent, an acidic reagent or a hydrogenolysis catalyst

The present invention relates to a process for the preparation of an amino phosphate ester derivative having antiviral activity as shown in the general formula (I) and a process for the preparation of intermediates and intermediates thereof, characterized in that at 0 DEG C -100 DEG C and in a solvent, the compound represented by the general formula (II) is subjected to an amino deprotection reaction in the presence of an alkaline reagent, an acidic reagent or a hydrogenolysis catalyst; the solvent used in the reaction is selected one or two from the group consisting of alcohol solvents, aromatic hydrocarbon solvents, ether solvents, halogenated alkane solvents, ester solvents, ketone solvents, lipid solvents, amide solvents, sulfoxide solvents and water; the acidic reagent is selected from organic acids or inorganic acids; the alkaline reagent is selected one or two from the group consisting of alkali metal hydroxides, alkaline earth metal hydroxides, alkali metal carbonates, alkaline earth metal carbonates and organic amines.