34273-01-3

Basic information

• Product Name: 4-N-Methylbenzyl-N-carbethoxypiperidine dihydrochloride
• Synonyms: 4-N-Methylbenzyl-N-carbethoxypiperidine dihydrochloride
• CAS NO: 34273-01-3
• Molecular Formula: C₁₇H₁₉N
• Molecular Weight: 335.28914
• Mol File: 34273-01-3.mol
• Article Data: 6

Chemical Properties

• Appearance: /
• CAS DataBase Reference: 4-N-Methylbenzyl-N-carbethoxypiperidine dihydrochloride(CAS DataBase Reference)
• NIST Chemistry Reference: 4-N-Methylbenzyl-N-carbethoxypiperidine dihydrochloride(34273-01-3)
• EPA Substance Registry System: 4-N-Methylbenzyl-N-carbethoxypiperidine dihydrochloride(34273-01-3)

Safety Data

• Hazardous Substances Data: 34273-01-3(Hazardous Substances Data)

Upstream product

• 71-43-2 benzene 
• 73390-11-1 4-piperidinone monohydrate 
• 14554-17-7 N-benzyl-3-benzoyl-4-hydroxy-4-phenylpiperidine 
• 63843-83-4 1-benzyl-4-hydroxy-4-phenylpiperidine 
• 3612-20-2 1-phenylmethyl-4-piperidone 
• 41979-39-9 4-piperidone hydrochloride 
• 177-11-7 4,4-ethylenedioxy-piperidine 
• 40807-61-2 4-hydroxy-4-phenylpiperidin 
• 108-90-7 chlorobenzene 
• 40105-95-1 4,4-diphenyl-N-benzylpiperidine 
• 10338-69-9 1,2,3,6-tetrahydro-4-phenylpyridine 
• 41661-47-6 piperidin-4-one 

Downstream Products

• 91075-45-5 1-n-butyl-4,4-diphenylpiperidine 
• 35879-51-7 1-acetonyl-4,4-diphenylpiperidine 
• 35985-34-3 1-(3-hydroxypropyl)-4,4-diphenylpiperidine 
• 321403-60-5 [2-(4-chlorobenzyl)-1H-imidazol-5-yl](4,4-diphenyl-1-piperidinyl)methanone 
• 321403-16-1 1-[(1-benzyl-1H-pyrazol-3-yl)methyl]-4,4-diphenylpiperidine 
• 40421-34-9 bis-4-(4-chlorophenyl)piperidine 

Relevant articles and documents

para-Selective arylation and alkenylation of monosubstituted arenes using thianthreneS-oxide as a transient mediator

Using thianthreneS-oxide (TTSO) as a transient mediator,para-arylation and alkenylation of mono-substituted arenes have been demonstratedviaapara-selective thianthrenation/Pd-catalyzed thio-Suzuki-Miyaura coupling sequence under mild conditions. This reaction features a broad substrate scope, and functional group and heterocycle tolerance. The versatility of this approach was further demonstrated by late-stage functionalization of complex bioactive scaffolds, and direct synthesis of some pharmaceuticals, including Tetriprofen, Ibuprofen, Bifonazole, and LJ570.

Bicyclic Benzimidazole Compounds and Their Use as Metabotropic Glutamate Receptor Potentiators

Compounds of Formula I: wherein A, B, D, L, R1, R2, R3, R4, m, and n are as defined for Formula I in the description. The invention also relates to processes for the preparation of the compounds and to new intermediates employed in the preparation, pharmaceutical compositions containing the compounds, and to the use of the compounds in therapy.

Synthesis of aryl-substituted piperidines by superacid activation of piperidones

Diarylpiperidines (8-12) may be prepared in good to excellent yields (80-99%) by the reaction of piperidones (3d-h) with benzene and the Bronsted superacid, trifluoromethanesulfonic acid (CF3-SO3H, TfOH). Tropinone (6) and quinuclidone (7) also react in good yields with benzene in TfOH to give the condensation products (13 and 14). Ketal and acetal derivatives also give condensation products (8 and 24) upon reaction with C6H6 in TfOH. The conversion of 3g to 11 is sensitive to both acid quantity and acid strength; a mechanism is proposed for the conversion that invokes dicationic intermediates.