342808-35-9

Basic information

• Product Name: 1,4-Pentadien-3-one, 1,5-bis(2,6-dimethoxyphenyl)-
• CAS NO: 342808-35-9
• Molecular Formula: C21H22O5
• Molecular Weight: 354.403
• Mol File: 342808-35-9.mol
• Article Data: 3

Chemical Properties

• CAS DataBase Reference: 1,4-Pentadien-3-one, 1,5-bis(2,6-dimethoxyphenyl)-(CAS DataBase Reference)
• NIST Chemistry Reference: 1,4-Pentadien-3-one, 1,5-bis(2,6-dimethoxyphenyl)-(342808-35-9)
• EPA Substance Registry System: 1,4-Pentadien-3-one, 1,5-bis(2,6-dimethoxyphenyl)-(342808-35-9)

Safety Data

• Hazardous Substances Data: 342808-35-9(Hazardous Substances Data)

Upstream product

• 112-02-7 cetyltrimethylammonium chloride 
• 3392-97-0 2,6-dimethoxybenzaldehyde 
• 67-64-1 acetone 

Relevant articles and documents

Effects of diarylpentanoid analogues of curcumin on chemiluminescence and chemotactic activities of phagocytes

Objectives A series of 43 curcumin diarylpentanoid analogues were synthesized and evaluated for their inhibitory effects on the chemiluminescence and chemotactic activity of phagocytes in vitro. Methods The effects of the compounds on the respiratory burst of human whole blood and isolated human polymorphonuclear leukocytes (PMNs) were evaluated using a luminol-based chemiluminescence assay and their effect on chemotactic migration of PMNs was investigated using the Boyden chamber technique. Key findings Compounds 6, 17, 25 and 30 exhibited significant inhibitory activity on the oxidative burst of PMNs. The presence of methoxy groups at positions 2 and 5, and methoxylation and fluorination at positions 4 and 2 of both phenyl rings, respectively, may contribute significantly to their reactive oxygen species inhibition activity. Compounds 7, 17, 18, 24 and 32 showed strong inhibition of the chemotaxis migration of PMNs. Chlorination at various positions of both phenyl rings of cyclohexanone diarylpentanoid resulted in compounds with potent inhibitory effects on PMN migration. Conclusions The results suggest that some of these diarylpentanoid analogues are able to modulate the innate immune response of phagocytes at different steps, emphasizing their potential as a source of new immunomodulatory agents.

Curcumin analogs with anti-tumor and anti-angiogenic properties

The present invention is directed to curcumin analogs exhibiting anti-tumor and anti-angiogenic properties, pharmaceutical formulations including such compounds and methods of using such compounds.