342889-39-8

Basic information

• Product Name: 4-(3-Chloro-2-fluorophenyl)benzaldehyde
• Synonyms: 4-(3-Chloro-2-fluorophenyl)benzaldehyde;4-(4-Chloro-2-fluorophenyl)benzaldehyde;4-(5-Chloro-2-fluorophenyl)benzaldehyde;4-(Benzo[1,3]dioxol-5-yl)benzaldehyde;4-(1,3-Benzodioxol-5-yl)-benzaldehyde;Benzaldehyde,4-(1,3-benzodioxol-5-yl)-
• CAS NO: 342889-39-8
• Molecular Formula: C₁₄H₁₀O₃
• Molecular Weight: 226.23
• Mol File: 342889-39-8.mol
• Article Data: 7

Chemical Properties

• Melting Point: 102～104℃
• Appearance: /
• CAS DataBase Reference: 4-(3-Chloro-2-fluorophenyl)benzaldehyde(CAS DataBase Reference)
• NIST Chemistry Reference: 4-(3-Chloro-2-fluorophenyl)benzaldehyde(342889-39-8)
• EPA Substance Registry System: 4-(3-Chloro-2-fluorophenyl)benzaldehyde(342889-39-8)

Safety Data

• Hazardous Substances Data: 342889-39-8(Hazardous Substances Data)

Upstream product

• 1122-91-4 4-bromo-benzaldehyde 
• 94839-07-3 3,4-(methylenedioxy)-benzeneboronic acid 
• 2635-13-4 1,2-(methylenedioxy)-4-bromobenzene 
• 87199-17-5 4-formylphenylboronic acid, 

Downstream Products

• 918799-88-9 N-(4-benzo[1,3]dioxol-5-yl-benzyl)-N-[(methoxy-methyl-carbamoyl)-methyl]-4-pentyl-benzamide 
• 918799-87-8 [(4-benzo[1,3]dioxol-5-yl-benzyl)-(4-pentyl-benzoyl)-amino]-acetic acid methyl ester 
• 918799-89-0 N-(4-benzo[1,3]dioxol-5-yl-benzyl)-N-(2-oxo-ethyl)-4-pentyl-benzamide 

Relevant articles and documents

Structure-Activity Relationship and Mode-Of-Action Studies Highlight 1-(4-Biphenylylmethyl)-1H-imidazole-Derived Small Molecules as Potent CYP121 Inhibitors

CYP121 of Mycobacterium tuberculosis (Mtb) is an essential target for the development of novel potent drugs against tuberculosis (TB). Besides known antifungal azoles, further compounds of the azole class were recently identified as CYP121 inhibitors with

PIPERIDINES USEFUL FOR THE TREATMENT OF CENTRAL NERVOUS SYSTEM DISORDERS

The invention relates to compounds which are substituted chiral or achiral derivatives of 3- or 4- aminopiperidine of the general formula (I). The invention also concerns related aspects including processes for the preparation of the compounds, pharmaceutical compositions containing one or more compounds of general formula I and especially their use as inhibitors of β-secretases.

Catalyst for aromatic C—O, C—N, and C—C bond formation

The present invention is directed to a transition metal catalyst, comprising a Group 8 metal and a ligand having the structure wherein R, R′ and R″ are organic groups having 1-15 carbon atoms, n=1-5, and m=0-4. The present invention is also directed to a method of forming a compound having an aromatic or vinylic carbon-oxygen, carbon-nitrogen, or carbon-carbon bond using the above catalyst. The catalyst and the method of using the catalyst are advantageous in preparation of compounds under mild conditions of approximately room temperature and pressure.