343-93-1

Basic information

• Product Name: 6-FLUOROGRAMINE
• Synonyms: 3-(DIMETHYLAMINOMETHYL)-6-FLUOROINDOLE;6-FLUOROGRAMINE;6-FLUORO-3-[DIMETHYLAMINOMETHYL]-INDOLE;3-(Dimethylaminomethyl)-6-fluoro-1H-indole;6-FLUOROFLAVONE;[(6-fluoro-1H-indol-3-yl)methyl]dimethylamine
• CAS NO: 343-93-1
• Molecular Formula: C₁₁H₁₃FN₂
• Molecular Weight: 192.23
• Product Categories: Indoles and derivatives
• Mol File: 343-93-1.mol
• Article Data: 6

Chemical Properties

• Boiling Point: 297.7 °C at 760 mmHg
• Flash Point: 133.8 °C
• Appearance: /
• Density: 1.181 g/cm³
• Vapor Pressure: 0.00133mmHg at 25°C
• Refractive Index: 1.61
• Storage Temp.: 2-8°C
• CAS DataBase Reference: 6-FLUOROGRAMINE(CAS DataBase Reference)
• NIST Chemistry Reference: 6-FLUOROGRAMINE(343-93-1)
• EPA Substance Registry System: 6-FLUOROGRAMINE(343-93-1)

Safety Data

• Hazard Codes: Xi
• WGK Germany: 3
• Hazardous Substances Data: 343-93-1(Hazardous Substances Data)

Usage

General Description

6-Fluorogramine is a chemical compound that belongs to the family of indoles, specifically tryptamines, which originate from amino acids and are often associated with bioactive properties. The major distinguishing aspect of 6-Fluorogramine is the presence of a fluorine atom, which is known for its high electronegativity and small size. As such, it often imparts unique characteristics to the substances it is part of. While there isn't much specific documentation about 6-Fluorogramine, chemicals within the fluorine and tryptamines categories are known for their potential use in pharmaceuticals and psychoactive drugs. It's essential to handle such chemicals with care due to their potential bioactivity.

InChI:InChI=1/C11H13FN2/c1-14(2)7-8-6-13-11-5-9(12)3-4-10(8)11/h3-6,13H,7H2,1-2H3

Upstream product

• 399-51-9 6-fluoro-1H-indole 
• 50-00-0 formaldehyd 
• 124-40-3 dimethyl amine 
• 462-95-3 formaldehyde diethyl acetal 

Downstream Products

• 2341-25-5 2-(6-fluoro-1H-indol-3-yl)acetonitrile 
• 467458-02-2 [2-(6-fluoro-1H-indol-3-yl)ethyl]({[3-(2,2,3,3-tetrafluoropropoxy)phenyl]methyl})amine HCl salt 
• 61-54-1 tryptamine 
• 575-85-9 6-fluorotryptamine 
• 443-75-4 2-(6-fluoro-1H-indol-3-yl)acetic acid 

Relevant articles and documents

Synthesis and Preclinical Evaluation of 6-[18F]Fluorine-α-methyl- l -tryptophan, a Novel PET Tracer for Measuring Tryptophan Uptake

The positron emission tomography (PET) radioligand α-[11C]methyl-l-tryptophan ([11C]AMT) has been used to assess tryptophan metabolism in cancer, epilepsy, migraine, and autism. Despite its extensive application, the utility of this tracer is currently hampered by the short half-life of the radionuclide used for its labeling (11C, t1/2 = 20.4 min). We herein report the design, synthesis, radiolabeling, and initial in vivo evaluation of a fluorine-18 (18F, t1/2 = 109.7 min) labeled analogue that is fluorinated in the 6-position of the aromatic ring ([18F]6-F-AMTr). In a head-to-head comparison between [18F]6-F-AMTr and [11C]AMT in mice using PET, peak brain radioactivity, regional brain distribution, and kinetic profiles were similar between the two tracers. [18F]6-F-AMTr was however not a substrate for IDO1 or TPH as determined in in vitro enzymatic assays. The brain uptake of the tracer is thus more likely related to LAT1 transport over the blood-brain barrier than metabolism along the serotonin or kynurenine pathways.

PROCESS FOR THE MANUFACTURE OF IDALOPIRDINE

Disclosed herein is a process for the preparation of idalopirdine and pharmaceutically acceptable salts thereof.

PROCESSES FOR THE MANUFACTURE OF A PHARMACEUTICALLY ACTIVE AGENT

Disclosed herein are processes for the preparation of a pharmaceutically active agent and pharmaceutically acceptable salts thereof.