34322-45-7

Basic information

• Product Name: PYRIDINE (15N)
• Synonyms: PYRIDINE (15N);PYRIDINE-15N, 99 ATOM % 15N
• CAS NO: 34322-45-7
• Molecular Formula: C₅H₅N
• Molecular Weight: 80.11
• Product Categories: Alphabetical Listings;P;Stable Isotopes
• Mol File: 34322-45-7.mol
• Article Data: 3

Chemical Properties

• Melting Point: −42 °C(lit.)
• Boiling Point: 115 °C(lit.)
• Flash Point: 68 °F
• Appearance: /
• Density: 0.990 g/mL at 25 °C
• Vapor Pressure: 10 mm Hg ( 13.2 °C)
• Storage Temp.: Refrigerator
• Solubility: Chloroform (Sparingly), Methanol (Slightly)
• CAS DataBase Reference: PYRIDINE (15N)(CAS DataBase Reference)
• NIST Chemistry Reference: PYRIDINE (15N)(34322-45-7)
• EPA Substance Registry System: PYRIDINE (15N)(34322-45-7)

Safety Data

• Hazard Codes: F,Xn
• Statements: 11-20/21/22
• Safety Statements: 16-23-26-36-28
• RIDADR: UN 1282 3/PG 2
• WGK Germany: 3
• Hazardous Substances Data: 34322-45-7(Hazardous Substances Data)

Usage

Description

PYRIDINE (15N) is a labeled analogue of Pyridine, which is a basic six-membered heterocyclic ring. It serves as a base structure in various biologically active compounds, such as vitamins niacin and pyridoxal. PYRIDINE (15N) is characterized by its unique nitrogen isotope labeling, which allows for specific applications in different fields.

Uses

Used in Chemical Synthesis:
PYRIDINE (15N) is used as a synthetic building block for the creation of various biologically active compounds. Its presence in vitamins like niacin and pyridoxal highlights its importance in the synthesis of essential nutrients.
Used in Dehalogenation Reactions:
PYRIDINE (15N) is utilized as a reagent in dehalogenation reactions, where it aids in the removal of halogen atoms from organic compounds. This application is crucial for the synthesis of compounds with specific functional groups and for the production of environmentally friendly chemicals.
Used in Condensation Reactions:
As a base, PYRIDINE (15N) is employed in condensation reactions, facilitating the formation of larger molecules from smaller ones. This is particularly useful in the synthesis of complex organic compounds and pharmaceuticals.
Used in Analytical Chemistry:
The nitrogen isotope labeling of PYRIDINE (15N) makes it an ideal candidate for use in analytical chemistry. It can be employed as a tracer or internal standard, allowing for the accurate measurement and quantification of various compounds in complex mixtures.
Used in Pharmaceutical Research:
PYRIDINE (15N) plays a significant role in pharmaceutical research, as it is a part of the molecular structure of many active ingredients. Its unique properties can be harnessed to develop new drugs or improve the efficacy of existing ones.
Used in Environmental Science:
In environmental science, PYRIDINE (15N) can be used to study the fate and transport of pollutants, as well as to understand the processes involved in the degradation of contaminants in the environment.
Used in Material Science:
The unique properties of PYRIDINE (15N) can be exploited in the development of new materials with specific characteristics, such as improved conductivity or enhanced stability.

Upstream product

• 110-86-1 pyridine 
• 103-75-3 2-ethoxy-2,3-dihydro-4H-pyran 

Downstream Products

• 1099707-70-6 Ir(triphenylphosphine)(tri(anisolyl)phosphine)(pyridine)2(H₂)BF₄ 
• 1099707-67-1 Ir(triphenylphosphine)(tri(p-tolyl)phosphine)(pyridine)2(H₂)BF₄ 
• 20574-17-8 cis,cis,trans-dihydrido(carbonyl)2(triphenylphosphine)2ruthenium(II) 
• 239076-81-4 mer-[Ru(CO)3(H)2(triphenylphosphine)] 
• 239076-81-4 fac-[Ru(CO)3(H)2(triphenylphosphine)] 

Relevant articles and documents

15N MRI of SLIC-SABRE Hyperpolarized 15N-Labelled Pyridine and Nicotinamide

Magnetic Resonance Imaging (MRI) is a powerful non-invasive diagnostic method extensively used in biomedical studies. A significant limitation of MRI is its relatively low signal-to-noise ratio, which can be increased by hyperpolarizing nuclear spins. One promising method is Signal Amplification By Reversible Exchange (SABRE), which employs parahydrogen as a source of hyperpolarization. Recent studies demonstrated the feasibility to improve MRI sensitivity with this hyperpolarization technique. Hyperpolarized 15N nuclei in biomolecules can potentially retain their spin alignment for tens of minutes, providing an extended time window for the utilization of the hyperpolarized compounds. In this work, we demonstrate for the first time that radio-frequency-based SABRE hyperpolarization techniques can be used to obtain 15N MRI of biomolecule 1-15N-nicotinamide. Two image acquisition strategies were utilized and compared: Single Point Imaging (SPI) and Fast Low Angle SHot (FLASH). These methods demonstrated opportunities of high-field SABRE for biomedical applications.

A versatile synthetic route to the preparation of 15N heterocycles

A robust medium-scale (approximately 3 g) synthetic method for 15N labeling of pyridine (15N-Py) is reported based on the Zincke reaction. 15N enrichment in excess of 81% was achieved with approximately 33% yield. 15N-Py serves as a standard substrate in a wide range of studies employing a hyperpolarization technique for efficient polarization transfer from parahydrogen to heteronuclei; this technique, called SABRE (signal amplification by reversible exchange), employs a simultaneous chemical exchange of parahydrogen and a to-be-hyperpolarized substrate (e.g., pyridine) on metal centers. In studies aimed at the development of hyperpolarized contrast agents for in vivo molecular imaging, pyridine is often employed either as a model substrate (for hyperpolarization technique development, quality assurance, and phantom imaging studies) or as a co-substrate to facilitate more efficient hyperpolarization of a wide range of emerging contrast agents (e.g., nicotinamide). Here, the produced 15N-Py was used for the feasibility study of spontaneous 15N hyperpolarization at high magnetic (HF) fields (7 T and 9.4 T) of an NMR spectrometer and an MRI scanner. SABRE hyperpolarization enabled acquisition of 2D MRI imaging of catalyst-bound 15N-pyridine with 75 × 75 mm2 field of view (FOV), 32 × 32 matrix size, demonstrating the feasibility of 15N HF-SABRE molecular imaging with 2.4 × 2.4 mm2 spatial resolution.