34328-54-6Relevant articles and documents
Qualitative and quantitative analysis of the active components of the essential oil from Brickellia veronicaefolia by nuclear magnetic resonance spectroscopy
Rivero-Cruz, Blanca,Rivero-Cruz, Isabel,Rodriguez, Juan M.,Cerda-Garcia-Rojas, Carlos M.,Mata, Rachel
, p. 1172 - 1176 (2006)
The composition of the spasmolytic essential oil of the medicinal species Brickellia veronicaefolia was established by NMR spectroscopy in addition to GC-MS analysis and HPLC studies. Seven major compounds, representing ca. 86% of the oil, were identified as benzyl 2,6-dimethoxybenzoate (1), 2-hydroxybenzyl 2′-methoxybenzoate (2), chamazulene (3), β-caryophyllene (4), germacrene D (5), bicyclogermacrene (6), and β-eudesmol (7). A sensitive and accurate analytical 1H NMR method has been developed for the quantification of the major compounds in the essential oil of B. veronicaefolia. The method was validated using benzyl 2,6-dimethoxybenzoate (1) and β-caryophyllene (4), two of the active principles in the oil, and successfully applied to the determination of these pharmacologically active compounds in three different batches of the oil collected in different geographical regions and/or seasons.
Simplification of the Mitsunobu reaction. Di-p-chlorobenzyl azodicarboxylate: A new azodicarboxylate
Lipshutz, Bruce H.,Chung, David W.,Rich, Brian,Corral, Ricardo
, p. 5069 - 5072 (2007/10/03)
(Chemical Equation Presented) Di-p-chlorobenzyl azodicarboxylate (DCAD) is introduced as a novel, stable, solid alternative to DEAD and DIAD for a variety of Mitsunobu couplings. DCAD/Ph3P-mediated reactions in CH 2Cl2 gen
