343569-07-3Relevant articles and documents
Synthesis of xestomanzamines a and b
Burm, Brigitte E.A.,Blokker, Peter,Jongmans, Edwin,Van Kampen, Erwin,Wanner, Martin J.,Koomen, Gerrit-Jan
, p. 495 - 503 (2007/10/03)
Synthetic pathways are described for the synthesis of two naturally occurring β-carbolines, xestomanzamine A and B. The synthesis of aromatic xestomanzamine A was most conveniently achieved by way of a Grignard reaction in dichloromethane. This route is suitable for the synthesis of analogues with modifications in the imidazole ring of xestomanzamine A. Xestomanzamine B, an oxidation-sensitive dihydro-β-carboline, was prepared by Pictet-Spengler condensation of tryptamine with a vicinal tricarbonyl substituted imidazole.