343781-56-6 Usage
General Description
2-BROMO-3,5-DICHLOROISONICOTINIC ACID is a chemical compound with the formula C6H2BrCl2NO2. It is a derivative of isonicotinic acid and is a halogenated pyridine compound. This chemical is used in the pharmaceutical industry as an intermediate in the synthesis of various drugs and active pharmaceutical ingredients. It is also used in the production of agrochemicals and other organic compounds. 2-BROMO-3,5-DICHLOROISONICOTINIC ACID is a white to off-white solid that is sparingly soluble in water and organic solvents. It is important to handle this compound with caution and follow proper safety procedures, as it may have harmful effects if not handled properly.
Check Digit Verification of cas no
The CAS Registry Mumber 343781-56-6 includes 9 digits separated into 3 groups by hyphens. The first part of the number,starting from the left, has 6 digits, 3,4,3,7,8 and 1 respectively; the second part has 2 digits, 5 and 6 respectively.
Calculate Digit Verification of CAS Registry Number 343781-56:
(8*3)+(7*4)+(6*3)+(5*7)+(4*8)+(3*1)+(2*5)+(1*6)=156
156 % 10 = 6
So 343781-56-6 is a valid CAS Registry Number.
InChI:InChI=1/C6H2BrCl2NO2/c7-5-4(9)3(6(11)12)2(8)1-10-5/h1H,(H,11,12)
343781-56-6Relevant articles and documents
Strategies for the selective functionalization of dichloropyridines at various sites
Marzi, Elena,Bigi, Anna,Schlosser, Manfred
, p. 1371 - 1376 (2007/10/03)
Whereas 2,3-dichloropyridine and 2,5-dichloro-4-(lithiooxy)-pyridine undergo deprotonation exclusively at the 4- and 2-positions, respectively, optional site selectivity can be implemented with 2,5- and 3,4-dichloropyridine (which are attacked, depending on the choice of the reagents, at either the 4- or 6- and either the 2- and 5-positions, respectively). Upon treatment with lithium diisopropylamide, 2,4-dichloro-3-iodopyridine, 3,5-dichloro-4-bromopyridine and 2,6-dichloro-3-iodopyridine afford 5-, 2- and 4-lithiated intermediates, but the latter isomerize instantaneously to species in which lithium and iodine have swapped places, the driving force being the low basicity of C-Li bonds when flanked by two neighboring halogens.
