34402-78-3 Usage
Description
METHYL 4-METHYL-1H-PYRROLE-2-CARBOXYLATE is an organic compound that serves as a crucial reagent in the synthesis of specific chemical compounds. It is characterized by its molecular structure and functional groups, which contribute to its reactivity and utility in various chemical reactions.
Uses
Used in Pharmaceutical Industry:
METHYL 4-METHYL-1H-PYRROLE-2-CARBOXYLATE is used as a reagent for the preparation of (E)-3-(2-(N-phenylcarbamoyl)vinyl)pyrrole-2-carboxylic acid derivatives. These derivatives represent a novel class of glycine site antagonists, which are important in the development of pharmaceuticals targeting the glycine site for various therapeutic applications.
The expression for the uses of METHYL 4-METHYL-1H-PYRROLE-2-CARBOXYLATE can be summarized as follows:
Used in Pharmaceutical Industry:
METHYL 4-METHYL-1H-PYRROLE-2-CARBOXYLATE is used as a reagent for the preparation of glycine site antagonists, specifically (E)-3-(2-(N-phenylcarbamoyl)vinyl)pyrrole-2-carboxylic acid derivatives, which have potential applications in the development of therapeutic drugs targeting the glycine site.
Check Digit Verification of cas no
The CAS Registry Mumber 34402-78-3 includes 8 digits separated into 3 groups by hyphens. The first part of the number,starting from the left, has 5 digits, 3,4,4,0 and 2 respectively; the second part has 2 digits, 7 and 8 respectively.
Calculate Digit Verification of CAS Registry Number 34402-78:
(7*3)+(6*4)+(5*4)+(4*0)+(3*2)+(2*7)+(1*8)=93
93 % 10 = 3
So 34402-78-3 is a valid CAS Registry Number.
InChI:InChI=1/C7H9NO2/c1-5-3-6(8-4-5)7(9)10-2/h3-4,8H,1-2H3
34402-78-3Relevant articles and documents
Phosphine-catalyzed regioselective heteroaromatization between activated alkynes and isocyanides leading to pyrroles
Kamijo, Shin,Kanazawa, Chikashi,Yamamoto, Yoshinori
, p. 2563 - 2566 (2005)
The organophosphine catalyzed reaction of activated alkynes with isocyanides produces the corresponding heteroaromatization products, pyrroles, regioselectively in good yields. The reaction proceeds most probably through the 1,4-addition of the nucleophil
Conversion of 4-oxoproline esters to 4-substituted pyrrole-2-carboxylic acid esters
Arakawa, Yasushi,Yagi, Naomi,Arakawa, Yukimi,Tanaka, Ken-Ichi,Yoshifuji, Shigeyuki
experimental part, p. 167 - 176 (2009/09/25)
The Grignard, Wittig, Tebbe, Horner-Emmons, and Reformatsky reactions of the 4-oxoproline esters gave the corresponding 4-alylated or 4-alkylidenated products, respectively. The products were properly treated with bases to cause aromatization, giving 4-su
Reversible Friedel-Crafts acylations of 3-alkyl-1-(phenylsulfonyl)pyrroles: Application to the synthesis of an ant trail pheromone
Xiao, Dong,Schreier, Jeffrey A.,Cook, James H.,Seybold, Paul G.,Ketcha, Daniel M.
, p. 1523 - 1526 (2007/10/03)
Friedel-Crafts acylations of 3-alkyl-1-(phenylsulfonyl)pyrroles appear to be kinetically favored at the adjacent C-2 position but rearrangement to the C-5 position can occur after prolonged reaction times. This reversible Friedel-Crafts methodology has been employed for the synthesis of the ant trail pheromone, methyl 4-methylpyrrole-2-carboxylate.