344324-66-9 Usage
Derivative of benzene
A compound based on the benzene structure, with modifications to the chemical structure, in this case, the addition of two iodine atoms and a methoxy group.
Iodine content
Contains two iodine atoms these heavy atoms can influence the compound's physical and chemical properties, such as reactivity and solubility.
Methoxy group attachment
A methoxy group (-OCH3) is attached to the benzene ring, which can affect the compound's polarity and reactivity.
Organic synthesis
1-Methoxy-3,5-diiodobenzene is used as an intermediate in organic synthesis, aiding in the creation of more complex organic molecules.
Reagent in chemical reactions
This compound serves as a reactant or catalyst in various chemical reactions, facilitating specific transformations.
Physical state
A pale yellow solid at room temperature, indicating its stability in this form and suggesting potential ease of storage and handling.
Strong odor
The compound has a noticeable and potentially irritating smell, which may require additional safety measures during handling.
Applications
Primarily used in the production of pharmaceuticals, agrochemicals, dyes, and pigments, highlighting its versatility in various industries.
Safety precautions
1-Methoxy-3,5-diiodobenzene may cause skin and eye irritation, so it is essential to handle it with care, use appropriate protective equipment, and work in a well-ventilated area to minimize exposure and potential health risks.
Check Digit Verification of cas no
The CAS Registry Mumber 344324-66-9 includes 9 digits separated into 3 groups by hyphens. The first part of the number,starting from the left, has 6 digits, 3,4,4,3,2 and 4 respectively; the second part has 2 digits, 6 and 6 respectively.
Calculate Digit Verification of CAS Registry Number 344324-66:
(8*3)+(7*4)+(6*4)+(5*3)+(4*2)+(3*4)+(2*6)+(1*6)=129
129 % 10 = 9
So 344324-66-9 is a valid CAS Registry Number.
344324-66-9Relevant articles and documents
Facile, One-Pot, and Gram-Scale Synthesis of 3,4,5-Triiodoanisole through a C-H Iodination/ipso-Iododecarboxylation Strategy: Potential Application towards 3,4,5-Trisubstituted Anisoles
Al-Zoubi, Raed M.,Al-Mughaid, Hussein,Al-Zoubi, Mariam A.,Jaradat, Khaled T.,McDonald, Robert
supporting information, p. 5501 - 5508 (2015/09/01)
A facile, efficient, and gram-scale method for the conversion of para-anisic acid into 3,4,5-triiodoanisole through a one-pot C-H iodination/ipso-iododecarboxylation reaction was investigated. Commercially available benzoic acid was used, which allowed the reaction to be performed on a multigram scale in good yield. This report discloses a practical method for the one-pot synthesis of hitherto unknown 3,4,5-triiodoanisole that is catalytic, scalable, efficient, and easy to work up and purify. Potential application of the target compound as a precursor for novel site-selective metal-iodine exchange and Suzuki-Miyaura cross-coupling reactions were also explored. 3,4,5-Trisubstituted anisole derivatives were provided in a highly regioselective fashion; these compounds are useful building blocks in synthesis and indeed are hard to prepare by any other means. The facile and efficient synthesis of hitherto unknown 3,4,5-triiodoanisole in a tandem one-pot C-H iodination/ipso-iododecarboxylation reaction that is catalytic, scalable, easy to work up, and easy to purify is disclosed. Potential application of the target compound as a precursor for novel site-selective metal-iodine exchange and Suzuki-Miyaura cross-coupling reactions are demonstrated.
