345-53-9

Basic information

• Product Name: 2-(4-fluorophenyl)-3-oxopentanenitrile
• Synonyms: 2-(4-fluorophenyl)-3-oxopentanenitrile
• CAS NO: 345-53-9
• Molecular Weight: 191.205
• Mol File: 345-53-9.mol
• Article Data: 3

Chemical Properties

• CAS DataBase Reference: 2-(4-fluorophenyl)-3-oxopentanenitrile(CAS DataBase Reference)
• NIST Chemistry Reference: 2-(4-fluorophenyl)-3-oxopentanenitrile(345-53-9)
• EPA Substance Registry System: 2-(4-fluorophenyl)-3-oxopentanenitrile(345-53-9)

Safety Data

• Hazardous Substances Data: 345-53-9(Hazardous Substances Data)

Upstream product

• 460-00-4 1-Bromo-4-fluorobenzene 
• 459-22-3 4-fluorophenylacetonitrile 
• 105-37-3 Ethyl propionate 
• 554-12-1 propanoic acid methyl ester 
• 33279-01-5 3-oxo-pentanenitrile 
• 352-34-1 4-fluoro-1-iodobenzene 

Downstream Products

• 1031699-69-0 3-ethyl-4-(4-fluorophenyl)-1H-pyrazol-5-amine 
• 314-75-0 6-ethyl-5-(4-fluoro-phenyl)-pyrimidine-2,4-diyldiamine 

Relevant articles and documents

Preparation of 3,4-Substituted-5-Aminopyrazoles and 4-Substituted-2-Aminothiazoles

3,4-Substituted-5-aminopyrazoles and 4-substituted-2-aminothiazoles are frequently used intermediates in medicinal chemistry and drug discovery projects. We report an expedient flexible synthesis of 3,4-substituted-5-aminopyrazoles (35 examples), based on palladium-mediated α-arylation of β-ketonitriles with aryl bromides. A library of 4-substituted-2-aminothiazoles (21 examples) was assembled by a sequence employing Suzuki coupling of newly prepared, properly protected pinacol ester and MIDA ester of 4-boronic acid-2-aminothiazole with (hetero)aryl halides.

Pyrazolotriazines as inhibitors of nucleases

The invention provides compounds represented by the structural formula (1): wherein R1, R2, R3 and R4 are as defined in the claims. The compounds are inhibitors of nucleases, and are useful in particular in a method of treatment and/or prevention of proliferative diseases, neurodegenerative diseases, and other genomic instability associated diseases.