34546-57-1Relevant articles and documents
Synthesis of (±)-15-thia-15-deoxy-PGE1 methyl ester
Holland,Ratemi,Contreras
, p. 1 - 5 (1994)
The 15-thia-15-deoxy analogue of prostaglandin E1 methyl ester has been prepared by the zirconocene chloride mediated conjugate addition of an n-pentyl ethynyl sulfide derived anion to an appropriately substituted cyclopentenone. Similar methodology has also been used to prepare other 3-(3'-thia-1'-octenyl)-cyclopentanones.
Synthesis of Methyl ο-(5-Oxo-1-cyclopentenyl)alkanoates Starting from 2-Nitrocycloalkanones
Stach, Hans,Hesse, Manfred
, p. 315 - 320 (1987)
A convenient synthesis of methyl ο-(5-oxo-1-cyclopentenyl)alkanoates 1 is described. 2-Nitrocycloalkanones 2 are converted to 2-(3,3-dimethoxypropyl)-2-nitrocycloalkanones 4.Treatment of 4 with MeOH/MeONa led to the ring-opened nitronates 5 which underwent a Nef reaction to form the corresponding oxo derivatives 6.Partial hydrolysis of 6 followed by base-catalyzed aldol reaction gave the desired products in high yields.
A New Synthesis of 2-(6-Methoxycarbonylhexyl)-cyclopent-2-en-1-one, An Important Prostanoid Synthon
Valcavi, Umberto,Farina, Paolo,Innocenti, Sergio,Marotta, Vittorio
, p. 124 - 125 (1983)
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Bagli,Bogri
, p. 2132,2137 (1972)
Synthons for 11-Deoxyprostaglandins of Series I and Their 11-Methyl-substituted Analogues Based on 2-Acylcyclohexane-1,3-diones
Lakhvich,Kozinets
, p. 42 - 46 (2007/10/03)
A convenient method for the synthesis of cyclopentenone synthons for 11-deoxyprostanoids including their 11-methyl-suhstituted analogues has been developed. 2-[ω-(Methoxycarbonyl)alkyl]cyclohexane-1,3-diones prepared by ionic hydrogenation of 2-[ω-(methoxycarbonyl)alkanoyl]cyclohexane-1,3-diones were chlorinated with tert-butyl hypochlorite, and the chlorination products were treated with anhydrous sodium carbonate to give the corresponding 2-alkyl-2-cyclopenten-1-ones and their 4-methyl-substituted derivatives as a result of the Favorskii rearrangement.
Process for preparing 7-(2-hexyl-5-hydroxy-cyclopentyl)-heptanoic acid
-
, (2008/06/13)
A multistep process for preparing 7-(2-hexyl-5-hydroxy-cyclopentyl)-heptanoic acid is described. Novel intermediates are also described.