345579-46-6

Basic information

• Product Name: Ethanone, 2-[[3,5-bis(trifluoromethyl)phenyl]methoxy]-1-phenyl-
• CAS NO: 345579-46-6
• Molecular Formula: C17H12F6O2
• Molecular Weight: 362.271
• Mol File: 345579-46-6.mol
• Article Data: 3

Chemical Properties

• CAS DataBase Reference: Ethanone, 2-[[3,5-bis(trifluoromethyl)phenyl]methoxy]-1-phenyl-(CAS DataBase Reference)
• NIST Chemistry Reference: Ethanone, 2-[[3,5-bis(trifluoromethyl)phenyl]methoxy]-1-phenyl-(345579-46-6)
• EPA Substance Registry System: Ethanone, 2-[[3,5-bis(trifluoromethyl)phenyl]methoxy]-1-phenyl-(345579-46-6)

Safety Data

• Hazardous Substances Data: 345579-46-6(Hazardous Substances Data)

Upstream product

• 912275-29-7 2-(3,5-bis(trifluoromethyl)benzyloxymethyl)-2-phenyl-[1,3]dioxolane 
• 184970-01-2 2-(3,5-bis(trifluoromethyl)benzyloxy)-N-methoxy-N-methylacetamide 
• 591-51-5 phenyllithium 
• 32707-89-4 3,5-bis(trifluoromethyl)benzenemethanol 
• 582-24-1 1-phenyl-2-hydroxyethanone 

Downstream Products

• 874470-27-6 2-((3,5-bis(trifluoromethyl)benzyloxy)methyl)-2-phenyloxirane 
• 912275-31-1 4-(3,5-bis(trifluoromethyl)benzyloxy)-3-phenyl-2-butenoic acid ethyl ester 
• 345577-77-7 4-(3,5-bis-trifluoromethyl-benzyloxymethyl)-4-phenyl-imidazolidin-2-one 
• 345580-16-7 (R)-4-(3,5-Bis-trifluoromethyl-benzyloxymethyl)-4-phenyl-imidazolidin-2-one 
• 345579-47-7 3-(3,5-bis-trifluoromethyl-benzyloxy)-2-phenyl-propane-1,2-diamine 
• 345580-10-1 2-amino-3-(3,5-bis-trifluoromethyl-benzyloxy)-2-phenyl-propionitrile 
• 345579-48-8 5-(3,5-bis-trifluoromethyl-benzyloxymethyl)-5-phenyl-imidazolidine-2,4-dione 

Relevant articles and documents

BENZYLOXYPROPYLAMINE DERIVATIVE

Disclosed is a novel benzyloxypropylamine derivative having an excellent tachykinin receptor antagonistic effect. This compound shows a good transfer into the blood and a long blood half-life in the blood kinetic test using a guinea pig orally administered with the compound and is stable in an animal plasma. The compound also shows a high transfer to the central nervous system when it is orally administered to a guinea pig at a certain dose. Accordingly, the benzyloxypropylamine derivative is quite useful as a novel anti-tachykinin agent.

Asymmetric Synthesis of 4,4-Disubstituted-2-Imidazoli-dinones: Potent NK1 Antagonists

(Equation presented) A highly efficient and practical synthesis of 4,4-Disubstituted-2-Imidazolidinones utilizing a "self-reproduction of the center of chirality" strategy is described.