345915-09-5

Basic information

• Product Name: isopropyl N-{5-({[(2S,4S)-1-(tert-butoxycarbonyl)-4-(pyridin-3-ylcarbonyl)thiopyrrolidin-2-yl]methyl}amino)-2-[2-(4-fluorophenyl)ethyl]benzoyl}-L-methioninate
• Synonyms: isopropyl N-{5-({[(2S,4S)-1-(tert-butoxycarbonyl)-4-(pyridin-3-ylcarbonyl)thiopyrrolidin-2-yl]methyl}amino)-2-[2-(4-fluorophenyl)ethyl]benzoyl}-L-methioninate
• CAS NO: 345915-09-5
• Molecular Weight: 752.972
• Mol File: 345915-09-5.mol
• Article Data: 1

Chemical Properties

• CAS DataBase Reference: isopropyl N-{5-({[(2S,4S)-1-(tert-butoxycarbonyl)-4-(pyridin-3-ylcarbonyl)thiopyrrolidin-2-yl]methyl}amino)-2-[2-(4-fluorophenyl)ethyl]benzoyl}-L-methioninate(CAS DataBase Reference)
• NIST Chemistry Reference: isopropyl N-{5-({[(2S,4S)-1-(tert-butoxycarbonyl)-4-(pyridin-3-ylcarbonyl)thiopyrrolidin-2-yl]methyl}amino)-2-[2-(4-fluorophenyl)ethyl]benzoyl}-L-methioninate(345915-09-5)
• EPA Substance Registry System: isopropyl N-{5-({[(2S,4S)-1-(tert-butoxycarbonyl)-4-(pyridin-3-ylcarbonyl)thiopyrrolidin-2-yl]methyl}amino)-2-[2-(4-fluorophenyl)ethyl]benzoyl}-L-methioninate(345915-09-5)

Safety Data

• Hazardous Substances Data: 345915-09-5(Hazardous Substances Data)

Upstream product

• 176486-58-1 [S-(R*,R*)]-2-[(N-Methoxy-N-methyl-amino)carbonyl]-4-[(triphenylmethyl)thio]-1-pyrrolidinecarboxylic acid, 1,1-dimethyl ethyl ester 
• 239064-77-8 O-mesyl-N-(tert-butoxycarbonyl)-hydroxyproline dimethylhydroxamide 
• 143775-30-8 (2S,4R)-1-(tert-butoxycarbonyl)-4-hydroxy-N-methoxy-N-methylprolinamide 
• 13726-69-7 (2S,4R)-4-hydroxy-1-[(2-methylpropan-2-yl)oxycarbonyl]pyrrolidine-2-carboxylic acid 
• 59-67-6 nicotinic acid 
• 59846-45-6 nicotinoyl imidazolide 
• 203855-07-6 methyl 5-amino-2-[2-(4-fluorophenyl)ethyl benzoate] 
• 405-99-2 para-fluorostyrene 
• 6307-82-0 2-chloro-5-nitro-benzoic acid methyl ester 

Downstream Products

• 345915-10-8 isopropyl N-{5-({[(2S,4S)-4-(pyridin-3-ylcarbonyl)thiopyrrolidin-2-yl]methyl}amino)-2-[2-(4-fluorophenyl)ethyl]benzoyl}-L-methioninate 
• 507-20-0 tertiary butyl chloride 
• 17348-59-3 isopropyl tert-butyl ether 

Relevant articles and documents

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An efficient manufacturing route to a novel farnesyl transferase inhibitor is described. The target molecule is a pro-drug, and its synthesis is complicated by the presence of labile functionality. The Medicinal Chemistry synthesis required trityl mercapt