346-44-1 Usage
Description
alpha,alpha,alpha-trifluoro-3-nitro-4-(phenylthio)toluene is a chemical compound with the molecular formula C13H8F3NO2S. It is a derivative of toluene and contains a trifluoromethyl group, a nitro group, and a phenylthio substituent. alpha,alpha,alpha-trifluoro-3-nitro-4-(phenylthio)toluene is known for its unique structural and chemical properties, making it a valuable building block in various fields.
Uses
Used in Organic Synthesis:
alpha,alpha,alpha-trifluoro-3-nitro-4-(phenylthio)toluene is used as a building block in organic synthesis for the preparation of various pharmaceuticals and agrochemicals. Its unique structure allows for the creation of a wide range of compounds with diverse applications.
Used in Pharmaceutical Research:
In the pharmaceutical industry, alpha,alpha,alpha-trifluoro-3-nitro-4-(phenylthio)toluene is used as a precursor in the production of fluorinated compounds. These compounds often possess improved pharmacological properties, such as increased lipophilicity and metabolic stability, making them more effective in treating various diseases.
Used in Pesticides:
alpha,alpha,alpha-trifluoro-3-nitro-4-(phenylthio)toluene is also used in the development of pesticides. Its unique chemical properties allow for the creation of more effective and targeted pest control agents, contributing to improved agricultural practices.
Used in Materials Science:
In the field of materials science, alpha,alpha,alpha-trifluoro-3-nitro-4-(phenylthio)toluene has potential applications in the synthesis of new materials with specific properties. Its unique structure can contribute to the development of advanced materials for various industries.
Used as a Reagent:
alpha,alpha,alpha-trifluoro-3-nitro-4-(phenylthio)toluene is used as a reagent in the synthesis of biologically active molecules. Its ability to participate in various chemical reactions makes it a valuable tool in the development of new compounds with potential therapeutic or other applications.
Check Digit Verification of cas no
The CAS Registry Mumber 346-44-1 includes 6 digits separated into 3 groups by hyphens. The first part of the number,starting from the left, has 3 digits, 3,4 and 6 respectively; the second part has 2 digits, 4 and 4 respectively.
Calculate Digit Verification of CAS Registry Number 346-44:
(5*3)+(4*4)+(3*6)+(2*4)+(1*4)=61
61 % 10 = 1
So 346-44-1 is a valid CAS Registry Number.
346-44-1Relevant articles and documents
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Bunnett,Davis
, p. 3011,3013 (1954)
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Microwave-promoted TBAF-catalyzed SNAr reaction of aryl fluorides and ArSTMS: An efficient synthesis of unsymmetrical diaryl thioethers
Liu, Chuanzhi,Zang, Xufeng,Yu, Baohua,Yu, Xiaochun,Xu, Qing
supporting information; experimental part, p. 1143 - 1148 (2011/07/09)
Microwave irradiation was found to promote tetrabutylammonium fluoride catalyzed nucleophilic aromatic substitution of aryl fluorides and arylthiotrimethylsilanes, affording high yields of unsymmetrical diaryl thioethers efficiently under mild, transition-metal- and base-free conditions. Microwave showed unusual improvement on the reaction in not only the conditions and reaction rate, but also in selectivity and substrate scope. Georg Thieme Verlag Stuttgart - New York.
The [Cu]-catalyzed SNAR reactions: Direct amination of electron deficient aryl halides with sodium azide and the synthesis of arylthioethers under Cu(II) - Ascorbate redox system
Goriya, Yogesh,Ramana
experimental part, p. 7642 - 7650 (2010/12/19)
A one pot [Cu]-promoted SNAr reaction of electron-deficient halobenzenes with sodium azide and the reduction of the intermediate aryl azides under the same Cu(II)-ascorbate redox conditions leading to anilines has been documented. Control experiments revealed that both ascorbate and proline play important role in the reaction path way. Further, the use of this catalytic Cu(II)-ascorbate redox system has been explored for the synthesis of arylthioethers.
