34604-60-9 Usage
Description
5-Hydroxypyrazine-2-carboxylic acid is an organic compound that serves as a versatile building block in chemical synthesis. It is a brownish powder and is also recognized as a metabolite of Pyrazinamide (P840600).
Uses
Used in Chemical Synthesis:
5-Hydroxypyrazine-2-carboxylic acid is used as a building block for [chemical synthesis] to facilitate the creation of new compounds and products. Its role as a building block is crucial due to its ability to be incorporated into various chemical structures, enhancing the development of new products.
Used in Pharmaceutical Industry:
In the pharmaceutical industry, 5-Hydroxypyrazine-2-carboxylic acid is used as a key component for [the synthesis of new antituberculous agents]. As a metabolite of Pyrazinamide, it plays a significant role in the development of treatments against tuberculosis, a disease that requires continuous innovation in therapeutic approaches.
Used in Development of New Products:
5-Hydroxypyrazine-2-carboxylic acid is utilized as a vital element in the [attributes development] of new products, particularly in the chemical and pharmaceutical sectors. Its unique properties allow it to contribute to the enhancement of product attributes, making it an indispensable component in the development process.
Check Digit Verification of cas no
The CAS Registry Mumber 34604-60-9 includes 8 digits separated into 3 groups by hyphens. The first part of the number,starting from the left, has 5 digits, 3,4,6,0 and 4 respectively; the second part has 2 digits, 6 and 0 respectively.
Calculate Digit Verification of CAS Registry Number 34604-60:
(7*3)+(6*4)+(5*6)+(4*0)+(3*4)+(2*6)+(1*0)=99
99 % 10 = 9
So 34604-60-9 is a valid CAS Registry Number.
InChI:InChI=1/C5H4N2O3/c8-4-2-6-3(1-7-4)5(9)10/h1-2H,(H,7,8)(H,9,10)
34604-60-9Relevant articles and documents
Redesign of the Synthesis and Manufacture of an Azetidine-Bearing Pyrazine
Hose, David R. J.,Hopes, Phillip,Steven, Alan,Herber, Christian
, p. 241 - 246 (2018)
Commercial route definition for a glucokinase activator called for a re-evaluation of the synthesis and processes used to access multikilogram quantities of a pyrazine building block. The processes developed allowed a literature route to sodium 6-oxo-1H-pyrazine-3-carboxylate to be leveraged. One of these processes consisted of a highly selective decarboxylation that allowed the target building block to be accessed with complete regioselectivity in standard batch processing equipment. The presence of an azetidine ring in the target required the mitigation of impurity liabilities arising from the use of the hydrochloride salt of azetidine as an input material.
Studies on Pyrazines. 7 (1). The Synthesis of 5-Chloropyrazinecarboxylic Acid
Sato, Nobuhiro,Arai, Shinji
, p. 407 - 408 (2007/10/02)
The titled carboxylic acid (1) was prepared by condensation of 2-furylglyoxal with aminoacetamide followed by chlorination of the resulting 2-hydroxy-5-(2'-furyl)pyrazine (2) and permanganate oxidation.The acid was further converted into methyl ester and 5-hydroxypyrazinecarboxylic acid.
