34619-89-1 Usage
Description
Beta-ketohexadecanoyl-coenzyme A, also known as 3-ketohexadecanoyl-CoA, is a crucial intermediate compound in the process of fatty acid metabolism. It is formed during the breakdown of fatty acids through a process called beta-oxidation. This molecule plays a significant role in the energy production pathway, as it is a key component in the conversion of fatty acids into energy within cells.
Uses
Used in Steroid Metabolism:
Beta-ketohexadecanoyl-coenzyme A is used as a substrate for 17β-hydroxysteroid dehydrogenase, an enzyme that plays a vital role in steroid metabolism. The enzyme is involved in the conversion of androstenedione to testosterone, which is essential for various physiological functions, including the development and maintenance of male characteristics, as well as the regulation of muscle mass and bone density.
Used in Energy Production:
As a part of the beta-oxidation process, beta-ketohexadecanoyl-coenzyme A is used as an intermediate in the breakdown of fatty acids to produce energy. This process is particularly important during periods of fasting or when the body requires additional energy, such as during exercise. The energy produced from the breakdown of fatty acids is used to fuel cellular activities and maintain overall metabolic health.
Used in Pharmaceutical Industry:
Beta-ketohexadecanoyl-coenzyme A may also have potential applications in the pharmaceutical industry, particularly in the development of drugs targeting metabolic disorders and conditions related to energy production and steroid metabolism. By understanding the role of this molecule in cellular processes, researchers can potentially develop therapies to modulate its activity, leading to improved treatment options for various diseases and conditions.
Check Digit Verification of cas no
The CAS Registry Mumber 34619-89-1 includes 8 digits separated into 3 groups by hyphens. The first part of the number,starting from the left, has 5 digits, 3,4,6,1 and 9 respectively; the second part has 2 digits, 8 and 9 respectively.
Calculate Digit Verification of CAS Registry Number 34619-89:
(7*3)+(6*4)+(5*6)+(4*1)+(3*9)+(2*8)+(1*9)=131
131 % 10 = 1
So 34619-89-1 is a valid CAS Registry Number.
InChI:InChI=1/C37H64N7O18P3S/c1-4-5-6-7-8-9-10-11-12-13-14-15-25(45)20-28(47)66-19-18-39-27(46)16-17-40-35(50)32(49)37(2,3)22-59-65(56,57)62-64(54,55)58-21-26-31(61-63(51,52)53)30(48)36(60-26)44-24-43-29-33(38)41-23-42-34(29)44/h23-24,26,30-32,36,48-49H,4-22H2,1-3H3,(H,39,46)(H,40,50)(H,54,55)(H,56,57)(H2,38,41,42)(H2,51,52,53)/t26-,30-,31-,32+,36-/m1/s1
34619-89-1Relevant articles and documents
One-pot synthesis of β-keto esters and preparation of 3-ketopalmitoyl-CoA
Ko?ak, Urban,Kova?, Andreja,Gobec, Stanislav
, p. 1609 - 1612 (2012/08/07)
β-Keto esters were synthesized from acyl chlorides and sodium ethyl acetoacetate in EtOH using a simple one-pot, one-step' method. The deacetylation of α-acetyl β-keto ester to β-keto ester was performed simply, by heating the reaction mixture at reflux for 12 hours, without the addition of additional reagents (e.g., NHl, NH MeOH, or NaOH). One of the β-keto esters prepared using this method was ethyl 3-oxohexadecanoate, a key intermediate in the synthesis of 3-ketopalmitoyl coenzyme A (3-oxohexadecanoyl coenzyme A), a potential substrate of the biologically important enzyme 17β-hydroxysteroid dehydrogenase type 12. Georg Thieme Verlag Stuttgart ? New York.
