34638-26-1

Basic information

• Product Name: 2H-Cyclopenta[b]furan-2-ol, 3,3a,6,6a-tetrahydro-
• CAS NO: 34638-26-1
• Molecular Formula: C7H10O2
• Molecular Weight: 126.155
• Mol File: 34638-26-1.mol
• Article Data: 4

Chemical Properties

• CAS DataBase Reference: 2H-Cyclopenta[b]furan-2-ol, 3,3a,6,6a-tetrahydro-(CAS DataBase Reference)
• NIST Chemistry Reference: 2H-Cyclopenta[b]furan-2-ol, 3,3a,6,6a-tetrahydro-(34638-26-1)
• EPA Substance Registry System: 2H-Cyclopenta[b]furan-2-ol, 3,3a,6,6a-tetrahydro-(34638-26-1)

Safety Data

• Hazardous Substances Data: 34638-26-1(Hazardous Substances Data)

Upstream product

• 26054-46-6 cis-(±)-2-oxabicyclo[3.3.0]oct-6-en-3-one 
• 34638-25-0 (1R,5S)-2-oxabicyclo[3.3.0]oct-6-en-3-one 

Downstream Products

• 118535-94-7 C₃₁H₂₅Cl₃O₆ 
• 118535-95-8 C₂₄H₂₂Cl₂O₅ 
• 118215-76-2 (4aS,5R,6aS,6bR)-3,5-Bis-benzyloxy-4,4a,5,6,6a,6b-hexahydro-3H-cyclopenta[cd]pentalen-1-one 
• 118215-77-3 C₂₄H₂₆O₃ 
• 118215-72-8 C₂₃H₂₄O₂ 

Relevant articles and documents

Enantioselective synthesis of cyclopentyltetrahydrofuran (Cp-THF), an important high-affinity P2-ligand for HIV-1 protease inhibitors

A convenient optically active synthesis of (3aS,5R,6aR)-5-hydroxy-hexahydrocyclopenta[b]furan, a high-affinity nonpeptidyl ligand for HIV-1 protease inhibitor 2, is described. The synthesis utilizes commercially available (1R,5S)-(+)-2-oxabicyclo[3.3.0]oct-6-en-3-one as the starting material and oxymercuration or bromohydrin reaction as the key step. Enantiopure ligand was converted to protease inhibitor 2.

SYNTHESIS AND CHIROPTICAL PROPERTIES OF C3-PERHYDROTRIQUINACENE DERIVATIVES

An efficient, enantioselective synthesis of C3-triketone 1, starting from optically pure lactone 2, which is commercially available in both enantiomeric forms, is described.The absolute configuration of a chiral perhydrotriquinacene derivative is therefore established for the first time by chemical correlation.The stereochemical assignments are also confirmed by the circular dichroism of both (+)-1, which shows a positive Cotton effect, and the tribenzoate (+)-12, which presents a positive exciton chirality.