34649-21-3

Basic information

• Product Name: 4,5-DIBROMO-1H-PYRROLE-2-CARBOXYLIC ACID
• Synonyms: 4,5-DIBROMO-1H-PYRROLE-2-CARBOXYLIC ACID;4,5-dibromo-2-pyrrolic acid;5-Carboxy-2,3-dibromo-1H-pyrrole
• CAS NO: 34649-21-3
• Molecular Formula: C₅H₃Br₂NO₂
• Molecular Weight: 268.89
• Mol File: 34649-21-3.mol
• Article Data: 11

Chemical Properties

• Melting Point: >300°C
• Boiling Point: 441.5°Cat760mmHg
• Flash Point: 220.8°C
• Appearance: /
• Density: 2.386g/cm³
• Vapor Pressure: 1.43E-08mmHg at 25°C
• Refractive Index: 1.688
• Storage Temp.: 2-8°C
• CAS DataBase Reference: 4,5-DIBROMO-1H-PYRROLE-2-CARBOXYLIC ACID(CAS DataBase Reference)
• NIST Chemistry Reference: 4,5-DIBROMO-1H-PYRROLE-2-CARBOXYLIC ACID(34649-21-3)
• EPA Substance Registry System: 4,5-DIBROMO-1H-PYRROLE-2-CARBOXYLIC ACID(34649-21-3)

Safety Data

• Hazard Codes: Xi
• HazardClass: IRRITANT
• Hazardous Substances Data: 34649-21-3(Hazardous Substances Data)

Usage

General Description

4,5-Dibromo-1H-Pyrrole-2-Carboxylic Acid is a brominated derivative of pyrrole carboxylic acid. As an organic compound, it belongs to the class of substances known as pyrrole carboxylic acids and derivatives. These are compounds containing a pyrrole ring, which is a five-member carbon ring with a nitrogen atom and a carboxylic acid attached. This chemical compound is not widely studied or widely used; detailed information on its properties such as physical state, color, solubility, stability, boiling or melting points may not be readily available. Therefore, information about its potential health effects or risks are also not well documented. Safety handling measures should be followed while dealing with such compounds.

InChI:InChI=1/C5H3Br2NO2/c6-2-1-3(5(9)10)8-4(2)7/h1,8H,(H,9,10)

Upstream product

• 634-97-9 pyrrole-2-carboxyl acid 
• 50371-52-3 4,5-dibromopyrrol-2-yl trichloromethyl ketone 
• 1003-29-8 2-pyrrole aldehyde 
• 35302-72-8 pyrrol-2-yl trichloromethyl ketone 

Downstream Products

• 1000612-07-6 C₂₇H₃₆N₄O₈SSi 
• 1000612-08-7 C₂₁H₂₂N₄O₈S 
• 1000612-09-8 C₂₁H₂₁N₄O₇SBr 
• 50371-37-4 4,4',5-tribromopyrrole-2-carboxanilide 
• 50371-36-3 3',4,5-tribromopyrrole-2-carboxanilide 
• 50371-39-6 3',4,5,5'-tetrabromopyrrole-2-carboxanilide 
• 50371-62-5 2',4,4',5-tetrabromopyrrole-2-carboxanilide 
• 1299491-42-1 4,5-dibromo-1H-pyrrole-2-carboxylic acid (3-methoxy-4-prop-2-ynyloxybenzyloxy)amide 
• 1299491-43-2 4,5-dibromo-1H-pyrrole-2-carboxylic acid (3,4-dimethoxybenzyloxy)amide 
• 1299491-45-4 4,5-dibromo-1H-pyrrole-2-carboxylic acid benzyloxyamide 
• 1299491-46-5 4,5-dibromo-1H-pyrrole-2-carboxylic acid (2-fluorobenzyloxy)amide 
• 1299491-47-6 4,5-dibromo-1H-pyrrole-2-carboxylic acid (3-fluorobenzyloxy)amide 
• 1299491-48-7 4,5-dibromo-1H-pyrrole-2-carboxylic acid (4-fluorobenzyloxy)amide 
• 1299491-49-8 4,5-dibromo-1H-pyrrole-2-carboxylic acid (2-chlorobenzyloxy)amide 

Relevant articles and documents

Synthesis of the antifouling polyamine pseudoceratidine and its analogs: Factors influencing biocidal activity

Syntheses of the title compound 1 and its N8 and N1-monoacylated analogs 5 and 8, respectively, are reported. Assays of 1, 5, and 8 indicate that the number and position of the acyl substituents affect bioactivity.

Pseudoceratidine, a marine natural product with antifouling activity: Synthetic and biological studies

Syntheses of pseudoceratidine and several analogs were developed in order to explore structure-activity relationships responsible for antifouling and antimicrobial activity.

Design, synthesis and antifungal activities of novel pyrrole alkaloid analogs

A series of novel analogs of pyrrole alkaloid were designed and synthesized by a facile method and their structures were characterized by 1H NMR, 13C NMR and high-resolution mass spectrometry (HRMS). The structure of compound 2a was identified by 2D NMR including heteronuclear multiple-quantum coherence (HMQC), heteronuclear multiple-bond correlation (HMBC) and H-H correlation spectrometry (H-H COSY) spectra. Their antifungal activities against five fungi were evaluated, and the results indicated that some of the title compounds showed moderate fungicidal activities in vitro against Alternaria solani, Cercospora arachidicola, Fusarium omysporum, Gibberella zeae and Physalospora piricola at the dosage of 50 μg mL -1. Compound 2a and 3a exhibited good activities against P. piricola at low dosage.

INHIBITION OF BACTERIAL BIOFILMS WITH IMIDAZOLE DERIVATIVES

Disclosure is provided for imidazole derivative compounds that prevent, remove and/or inhibit the formation of biofilms, compositions comprising these compounds, devices comprising these compounds, and methods of using the same.