34654-80-3

Basic information

• Product Name: 4-(3-Hydroxypropylamino)-1,3-dimethyluracil
• Synonyms: 4-(3-hydroxypropylamino)-1,3-dimethyluracil;6-(3-HYDROXYPROPYLAMINO)-1,3-DIMETHYLURACIL;[6-(3-chloro propyl) amino]-1,3-dimethyl urine pyridine;6-[(3-Hydroxypropyl)amino]-1,3-dimethyl-2,4(1H,3H)-pyrimidinedione;6-(3-hydroxypropylamino)-1,3-dimethylpyrimidine-2,4(1H,3H)-dione;6-(3-hydroxypropyl)aMino-1,3-diMethuracil
• CAS NO: 34654-80-3
• Molecular Formula: C₉H₁₅N₃O₃
• Molecular Weight: 213.23
• EINECS: 252-128-3
• Mol File: 34654-80-3.mol
• Article Data: 1

Chemical Properties

• Melting Point: 148-150 °C
• Boiling Point: 367.5 °C at 760 mmHg
• Flash Point: 176.1 °C
• Appearance: /
• Density: 1.295 g/cm³
• Storage Temp.: 2-8°C
• PKA: 15.03±0.10(Predicted)
• CAS DataBase Reference: 4-(3-Hydroxypropylamino)-1,3-dimethyluracil(CAS DataBase Reference)
• NIST Chemistry Reference: 4-(3-Hydroxypropylamino)-1,3-dimethyluracil(34654-80-3)
• EPA Substance Registry System: 4-(3-Hydroxypropylamino)-1,3-dimethyluracil(34654-80-3)

Safety Data

• Hazardous Substances Data: 34654-80-3(Hazardous Substances Data)

Usage

General Description

4-(3-hydroxypropylamino)-1,3-dimethyluracil, also known as HPUra, is a chemical compound with potential pharmaceutical applications. It belongs to the class of uracil derivatives and has a molecular formula of C9H13N3O2. HPUra has been studied for its potential antiviral and anticancer properties. It has been shown to inhibit the replication of certain viruses, including herpes simplex virus type 1, and has also demonstrated inhibitory effects on the growth of cancer cells. Its unique structure and biological activities make it a potentially valuable compound for further research and development in the field of medicine.

Upstream product

• 156-87-6 propan-1-ol-3-amine 
• 41949-07-9 6-hydroxy-1,3-dimethyluracil 

Downstream Products

• 34654-81-4 6?(3?chloropropyl)amino?1,3?dimethyluracil 

Relevant articles and documents

Synthesis method of urapidil medical intermediate 1,3-dimethyl-6-(3-hydroxy propyl)aminouracil

A synthesis method of a urapidil medical intermediate 1,3-dimethyl-6-(3-hydroxy propyl)aminouracil includes the following steps of adding 0.61 mol of 1,3-dimethyl-6-hydroxyl uracil (2), 0.72-0.75 mol of 3-amino-1-propanol and 0.16 mol of sodium sulfite solution to a reaction container provided with a stirrer, a thermometer and a reflux condenser, controlling the stirring speed at 130-160 rpm, raising the temperature of the solution to 150-160 DEG C, reacting for 90-120 min, lowering the temperature of the solution to 60-65 DEG C, adding 230 ml of cyclohexane, conducting refluxing for 30-50 min, conducting filtering, cooling filtrate to 5-9 DEG C, standing for 30-35 h, separating out crystals, conducting filtering, washing crystals with a saline solution and acetonitrile in sequence, conducting dehydration through a dehydrating agent, and conducting recrystallization in isopropanol to obtain white crystals 1,3-dimethyl-6-(3-hydroxy propyl)aminouracil.