346578-01-6

Basic information

• Product Name: (2S,4R)-2-Biphenyl-4-yl-4-(4-bromo-benzyl)-4-methyl-5-oxo-oxazolidine-3-carboxylic acid isobutyl ester
• Synonyms: (2S,4R)-2-Biphenyl-4-yl-4-(4-bromo-benzyl)-4-methyl-5-oxo-oxazolidine-3-carboxylic acid isobutyl ester
• CAS NO: 346578-01-6
• Molecular Weight: 522.439
• Mol File: 346578-01-6.mol
• Article Data: 2

Chemical Properties

• CAS DataBase Reference: (2S,4R)-2-Biphenyl-4-yl-4-(4-bromo-benzyl)-4-methyl-5-oxo-oxazolidine-3-carboxylic acid isobutyl ester(CAS DataBase Reference)
• NIST Chemistry Reference: (2S,4R)-2-Biphenyl-4-yl-4-(4-bromo-benzyl)-4-methyl-5-oxo-oxazolidine-3-carboxylic acid isobutyl ester(346578-01-6)
• EPA Substance Registry System: (2S,4R)-2-Biphenyl-4-yl-4-(4-bromo-benzyl)-4-methyl-5-oxo-oxazolidine-3-carboxylic acid isobutyl ester(346578-01-6)

Safety Data

• Hazardous Substances Data: 346578-01-6(Hazardous Substances Data)

Upstream product

• 3218-36-8 4-Phenylbenzaldehyde 
• 589-15-1 1-bromomethyl-4-bromobenzene 
• 346577-99-9 (2S,4S)-2-(biphenyl-4-yl)-4-methyl-5-oxo-oxazolidine-3-carboxylic acid isobutyl ester 
• 543-27-1 isobutyl chloroformate 
• 183140-29-6 N-isobutyloxycarbonyl-(S)-alanine 

Downstream Products

• 213208-73-2 (5R)-5-(4-bromobenzyl)-3-(3,5-dichlorophenyl)-5-methyl-1H-imidazole-2,4(3H,5H)-dione 

Relevant articles and documents

The formation of a crystalline oxazolidin-5-one from (L)-alanine and its use as a chiral template in the practical synthesis of α-substituted alanine esters

Three different protocols to synthesize oxazolidin-5-ones have been studied with the goal to develop a method to synthesize a diastereomerically pure oxazolidin-5-one. A novel method is reported that uses a dynamic crystallization-induced asymmetric transformation to isolate a single diastereomer of an oxazolidin-5-one in 92% yield on kilogram scale. Alkylation of the oxazolidin-5-one template leads to good-to-excellent yields of N-protected α-substituted alanine esters in >98-99% ee. Schweizerische Chemische Gesellschaft.