34658-67-8

Basic information

• Product Name: 2-(3-nitrophenyl)H-iMidazo[1,2-a]pyridine
• Synonyms: 2-(3-nitrophenyl)H-iMidazo[1,2-a]pyridine
• CAS NO: 34658-67-8
• Molecular Formula: C₁₃H₉N₃O₂
• Molecular Weight: 239.22946
• Mol File: 34658-67-8.mol
• Article Data: 24

Chemical Properties

• Appearance: /
• Density: 1.34 g/cm³
• Refractive Index: 1.686
• CAS DataBase Reference: 2-(3-nitrophenyl)H-iMidazo[1,2-a]pyridine(CAS DataBase Reference)
• NIST Chemistry Reference: 2-(3-nitrophenyl)H-iMidazo[1,2-a]pyridine(34658-67-8)
• EPA Substance Registry System: 2-(3-nitrophenyl)H-iMidazo[1,2-a]pyridine(34658-67-8)

Safety Data

• Hazardous Substances Data: 34658-67-8(Hazardous Substances Data)

Usage

General Description

2-(3-nitrophenyl)H-iMidazo[1,2-a]pyridine is a chemical compound with a complex molecular structure that includes a nitrophenyl group attached to a H-imidazo[1,2-a]pyridine ring. 2-(3-nitrophenyl)H-iMidazo[1,2-a]pyridine is a heterocyclic aromatic chemical that is often used in pharmaceutical research and development due to its potential pharmacological properties. It is known for its ability to act as an agonist or antagonist at various receptor sites in the body, making it a potential candidate for drug discovery. The nitrophenyl group in the molecule also provides opportunities for chemical modifications and derivatization to create novel compounds with enhanced biological activities. In addition, the H-imidazo[1,2-a]pyridine core structure is also of interest in medicinal chemistry due to its potential as a scaffold for developing new drug molecules. Overall, 2-(3-nitrophenyl)H-iMidazo[1,2-a]pyridine is a versatile and important chemical compound with potential applications in drug discovery and medicinal chemistry.

InChI:InChI=1/C13H9N3O2/c17-16(18)11-5-3-4-10(8-11)12-9-15-7-2-1-6-13(15)14-12/h1-9H

Upstream product

• 110-86-1 pyridine 
• 121231-58-1 1-(1-azidovinyl)-3-nitrobenzene 
• 53534-16-0 1-(1,2-dibromoethyl)-3-nitrobenzene 
• 504-29-0 2-aminopyridine 
• 3034-94-4 3-nitrophenylacetylene 
• 586-39-0 1-nitro-3-vinyl-benzene 
• 121-89-1 3-Nitroacetophenone 
• 882-26-8 3-nitro-β-nitrostyrene 
• 444681-65-6 1,1-dibromo-2-(3-nitrophenyl)ethene 
• 2227-64-7 3'-nitro-2-bromoacetophenone 

Downstream Products

• 537021-04-8 N-acetyl-sulfanilic acid-(3-imidazo[1,2-a]pyridin-2-yl-anilide) 
• 1417910-21-4 C₁₄H₁₀N₆O₂ 
• 1417910-30-5 2-(3-nitrophenyl)-3-((4-phenyl-1H-1,2,3-triazol-1-yl)methyl)-1H-imidazo[1,2-a]pyridine 
• 817172-42-2 C₁₄H₉N₃O₃ 
• 1192928-29-2 N-((3-imidazo[1,2-a]pyridin-2-yl)phenylcarbamothioyl)-3,4,5-trimethoxybenzamide 
• 1301138-37-3 3-iodo-2-(3-nitrophenyl)imidazo[1,2-a]pyridine 
• 1301134-22-4 N-(3-(3-(2-((2-methyl-1,2,3,4-tetrahydroisoquinolin-7-yl)amino)pyrimidin-4-yl)imidazo[1,2-a]pyridin-2-yl)phenyl)-N'-phenylurea 
• 1301134-19-9 2,6-difluoro-N-(3-(3-(2-(2-methyl-l,2,3,4-tetrahydroisoquinolin-7-ylamino)pyrimidin-4-yl)imidazo[1,2-a]pyridin-2-yl)phenyl)benzamide 
• 1301142-29-9 C₃₂H₃₃N₇O₃ 
• 1301138-49-7 C₂₇H₂₅N₇ 
• 1301138-48-6 C₂₇H₂₃N₇O₂ 

Relevant articles and documents

Solvent and catalyst-free synthesis of imidazo[1,2-a]pyridines by grindstone chemistry

The present work describes the solvent and catalyst-free synthesis of imidazo[1,2-a]pyridines in excellent to nearly quantitative yields from 2-aminopyridines and a wide variety of ω-bromomethylketones using a grindstone procedure at 25°C to 30°C for 3 to

Iodine mediated oxidative cross coupling of 2-aminopyridine and aromatic terminal alkyne: A practical route to imidazo[1,2-: A] pyridine derivatives

A novel, transition-metal free route leading to imidazo[1,2-a]pyridine derivatives via iodine mediated oxidative coupling between 2-aminopyridine and aromatic terminal alkyne has been demonstrated. This newly developed method discloses an operationally simple way for the construction of imidazoheterocycles. Commercially available antiulcer drug zolimidine may readily be synthesized employing this method.

Facile synthesis of imidazo[1,2-a]pyridines promoted by room-temperature ionic liquids under ultrasound irradiation

Abstract: A simple and efficient procedure for the synthesis of substituted imidazo[1,2-a]pyridines under ultrasound irradiation has been developed. The reactions were carried out using ionic liquids as catalyst. The reaction procedure demonstrated a broad substrate scope for both acetophenones and 2-aminopyridines, and provided convenient access to a wide variety of imidazo[1,2-a]pyridines. The present method offers several advantages compared to traditional heating methods such as higher yields, shorter reaction times, milder reaction conditions, and easier work-up procedure. Graphical abstract: [Figure not available: see fulltext.].