347-90-0

Basic information

• Product Name: 2-(3-FLUOROPHENYL)ACETOPHENONE
• Synonyms: 2-(3-FLUOROPHENYL)ACETOPHENONE;2-(3-FLUOROPHENYL)-1-PHENYLETHAN-1-ONE;2-(3-Fluorophenyl)-1-phenylethanone
• CAS NO: 347-90-0
• Molecular Formula: C₁₄H₁₁FO
• Molecular Weight: 214.23
• Mol File: 347-90-0.mol
• Article Data: 7

Chemical Properties

• Boiling Point: 319.2°C at 760 mmHg
• Flash Point: 131.4°C
• Appearance: /
• Density: 1.152g/cm³
• Vapor Pressure: 0.000344mmHg at 25°C
• Refractive Index: 1.567
• Storage Temp.: 2-8°C
• CAS DataBase Reference: 2-(3-FLUOROPHENYL)ACETOPHENONE(CAS DataBase Reference)
• NIST Chemistry Reference: 2-(3-FLUOROPHENYL)ACETOPHENONE(347-90-0)
• EPA Substance Registry System: 2-(3-FLUOROPHENYL)ACETOPHENONE(347-90-0)

Safety Data

• Statements: 36/37/38
• Safety Statements: 26-36/37/39
• Hazardous Substances Data: 347-90-0(Hazardous Substances Data)

Usage

General Description

2-(3-Fluorophenyl)acetophenone is a chemical compound with the molecular formula C14H11FO. It is a white to off-white solid that is insoluble in water but soluble in organic solvents. 2-(3-FLUOROPHENYL)ACETOPHENONE is used as a building block in the synthesis of various pharmaceuticals and organic compounds. It is also used as a reagent in research and chemical synthesis. 2-(3-Fluorophenyl)acetophenone has potential applications in the field of medicinal chemistry and drug discovery due to its ability to modulate biological processes. However, it should be handled and used with caution as it may pose health and environmental risks if not properly managed.

InChI:InChI=1/C14H11FO/c15-13-8-4-5-11(9-13)10-14(16)12-6-2-1-3-7-12/h1-9H,10H2

Upstream product

• 16717-64-9 1-azidostyrene 
• 658-27-5 m-fluorophenylhydrazine 
• 331-25-9 (3-fluorophenyl)acetic acid 
• 946402-22-8 N-methoxy-N-methyl-2-(3-fluorophenyl)acetamide 
• 100-58-3 phenylmagnesium bromide 
• 501-00-8 3-fluorophenylacetonitrile 
• 100-42-5 styrene 
• 98-88-4 benzoyl chloride 
• 352-70-5 m-Fluorotoluene 
• 611-73-4 Benzoylformic acid 

Downstream Products

• 3834-65-9 1-(3-fluorophenyl)-2-phenylethane-1,2-dione 
• 1283118-44-4 4-(3-ethoxy-4-hydroxy-5-nitrophenyl)-5-(3-fluorophenyl)-6-phenyl-3,4-dihydropyrimidin-2(1H)-one 

Relevant articles and documents

H2O2-mediated room temperature synthesis of 2-arylacetophenones from arylhydrazines and vinyl azides in water

An environmentally benign, cost-efficient and practical methodology for the room temperature synthesis of 2-arylacetophenones in water has been discovered. The facile and efficient transformation involves the oxidative radical addition of arylhydrazines with α-aryl vinyl azides in the presence of H2O2 (as a radical initiator) and PEG-800 (as a phase-transfer catalyst). From the viewpoint of green chemistry and organic synthesis, the present protocol is of great significance because of using cheap, non-toxic and readily available starting materials and reagents as well as amenability to gram-scale synthesis, which provides an attractive strategy to access 2-arylacetophenones.

Iron-Catalyzed Enantioselective Radical Carboazidation and Diazidation of α,β-Unsaturated Carbonyl Compounds

Azidation of alkenes is an efficient protocol to synthesize organic azides which are important structural motifs in organic synthesis. Enantioselective radical azidation, as a useful strategy to install a C-N3 bond, remains challenging due to the inherently instability and unique structure of radicals. Here, we disclose an efficient enantioselective radical carboazidation and diazidation of α,β-unsaturated ketones and amides catalyzed by chiral N,N′-dioxide/Fe(OTf)2 complexes. An array of substituted alkenes was transformed to the corresponding α-azido carbonyl derivatives in good to excellent enantioselectivities, benefiting the preparation of chiral α-amino ketones, vicinal amino alcohols, and vicinal diamines. Control experiments and mechanistic studies proved the radical pathway in the reaction process. The DFT calculations showed that the azido transferred to the radical intermediate via an intramolecular five-membered transition state with the internal nitrogen of the Fe-N3 species.

Catalyst-controlled highly selective coupling and oxygenation of olefins: A direct approach to alcohols, ketones, and diketones

Oxygen? That's radical! A method for the direct synthesis of substituted alcohols, ketones, and diketones through a catalyst-controlled highly chemoselective coupling and oxygenation of olefins has been developed. The method is simple and practical, can be switched by the selection of different catalysts, and employs molecular oxygen as both an oxidant and a reagent. Copyright