34801-09-7

Basic information

• Product Name: 2'-AMINOACETANILIDE
• Synonyms: N-(2-azanylphenyl)ethanamide;2'-Aminoacetanilide ,98%;N-(2-Aminophenyl)acetamide, 2-(Acetamido)aniline, N-Acetylphenylene-1,2-diamine;N-Acetyl-1,2-phenylenediamine 2'-Acetamidoaniline;2-AMinoactanilide;2'-Aminoacetanilide 98%;Acetanilide, 2-amino- (8CI);N-(2-aminophenyl)ethanamide
• CAS NO: 34801-09-7
• Molecular Formula: C₈H₁₀N₂O
• Molecular Weight: 150.18
• Product Categories: Benzenes;Nitrogen Compounds;Organic Building Blocks;Protected Amines;AMINEPRIMARY;Aromatic Carboxylic Acids, Amides, Anilides, Anhydrides & Salts
• Mol File: 34801-09-7.mol
• Article Data: 50

Chemical Properties

• Melting Point: 133-137 °C(lit.)
• Boiling Point: 271.72°C (rough estimate)
• Flash Point: 172.4 °C
• Appearance: /
• Density: 1.1392 (rough estimate)
• Refractive Index: 1.6180 (estimate)
• Storage Temp.: Keep in dark place,Inert atmosphere,Room temperature
• PKA: 14.73±0.70(Predicted)
• Water Solubility: 107.5g/L(22 oC)
• CAS DataBase Reference: 2'-AMINOACETANILIDE(CAS DataBase Reference)
• NIST Chemistry Reference: 2'-AMINOACETANILIDE(34801-09-7)
• EPA Substance Registry System: 2'-AMINOACETANILIDE(34801-09-7)

Safety Data

• Hazard Codes: Xi
• Statements: 36/37/38
• Safety Statements: 26-36
• WGK Germany: 3
• HazardClass: IRRITANT
• Hazardous Substances Data: 34801-09-7(Hazardous Substances Data)

Usage

Description

2'-Aminoacetanilide is an organic compound that serves as an important intermediate in the synthesis of various pharmaceuticals and dyes. It is characterized by its unique chemical structure, which includes an acetanilide group with an amino substituent at the 2' position.

Uses

Used in Pharmaceutical Industry:
2'-Aminoacetanilide is used as a key intermediate in the synthesis of 2-Methylbenzimidazole, a compound with potential pharmaceutical applications.
Used in Cystic Fibrosis Treatment:
In the pharmaceutical industry, 2'-Aminoacetanilide is utilized as a precursor for the synthesis of N-(2-(1,3-Dimethyl-2,4-dioxo-5-phenyl-3,4-dihydro-1H-pyrrolo[3,4-d]pyrimidin-6(2H)-yl)phenyl)-5-methylfuran-2-carboxamide. 2'-AMINOACETANILIDE is a potent inhibitor of the cystic fibrosis transmembrane conductance regulator (CFTR), making it a potential therapeutic agent for the treatment of cystic fibrosis.
Used in Dye Industry:
2'-Aminoacetanilide is used as a starting material in the production of Azobenzothiazole dyes, such as N-[2-(6-nitrobenzothiazol-2-ylazo)phenyl]acetamide and N-[2-(benzothiazol-2-ylazo)phenyl]acetamide. These dyes are known for their color properties and are used in various applications, including as pigments in inks, paints, and plastics.

Upstream product

• 19165-25-4 2-methyl-6-bromo-4H-3,1-benzoxazine-4-one 
• 95-54-5 1,2-diamino-benzene 
• 64-17-5 ethanol 
• 552-32-9 o-nitroacetanilide 
• 95635-45-3 N-(4-chloro-2-fluoro-5-nitrophenyl)acetamide 
• 7439-89-6 iron 
• 64-19-7 acetic acid 
• 62-53-3 aniline 
• 17716-46-0 2-acetamidoazobenzene 
• 103-84-4 Acetanilid 
• 71-43-2 benzene 
• 614-76-6 N-acetyl-2-bromoaniline 
• 88-74-4 2-nitro-aniline 
• 507-09-5 tiolacetic acid 

Downstream Products

• 106592-59-0 acetic acid-{2-[(1,3-dimethyl-2,4,6-trioxo-tetrahydro-pyrimidin-5-ylidenemethyl)-amino]-anilide} 
• 34442-95-0 N-(o-acetamidophenyl)phthalimide 
• 1087058-54-5 (2E,4E)-5-(3,4-methylenedioxyphenyl)-2,4-pentadienoic acid N-(2-acetylaminophenyl)amide 
• 77436-42-1 2-acetamido-2'-amino-ortho-azobenzene 
• 2050-85-3 N,N'-(o-phenylene)di(acetamide) 
• 18773-93-8 1-acetyl-1H-benzotriazole 
• 615-15-6 2-Methyl-1H-benzimidazole 
• 107682-66-6 acetic acid-{2-[3-(2-nitro-phenyl)-triazenyl]-anilide} 
• 107682-65-5 acetic acid-[2-amino-5-(3-nitro-phenylazo)-anilide] 
• 102025-08-1 acetic acid-(2-trans-cinnamylidenamino-anilide) 
• 95-54-5 1,2-diamino-benzene 

Relevant articles and documents

Proximity Histidine Labeling by Umpolung Strategy Using Singlet Oxygen

While electrophilic reagents for histidine labeling have been developed, we report an umpolung strategy for histidine functionalization. A nucleophilic small molecule, 1-methyl-4-arylurazole, selectively labeled histidine under singlet oxygen (1O2) generation conditions. Rapid histidine labeling can be applied for instant protein labeling. Utilizing the short diffusion distance of 1O2 and a technique to localize the 1O2 generator, a photocatalyst in close proximity to the ligand-binding site, we demonstrated antibody Fc-selective labeling on magnetic beads functionalized with a ruthenium photocatalyst and Fc ligand, ApA. Three histidine residues located around the ApA binding site were identified as labeling sites by liquid chromatography-mass spectrometry analysis. This result suggests that 1O2-mediated histidine labeling can be applied to a proximity labeling reaction on the nanometer scale.

Method for preparing O-phenylenediamine from aniline

The invention provides a method for preparing o-phenylenediamine from aniline. The method comprises the following steps: protecting an amino group on aniline by using an acetyl group, then mixing withan amino donor, an oxidant and a catalyst Pd-Cu/TS-1 to carry out an ammoniation reaction, carrying out deprotection, and separating to obtain o-phenylenediamine. A protecting group strategy is used,the acetyl group is adopted to protect the amino group on aniline, the catalyst is coordinated with a carbonyl group in acetanilide to induce and activate the o-position C-H bond, so the o-position selectivity is improved, the generation of byproducts is reduced, the ammoniation efficiency and selectivity can be greatly improved, and the yield and purity of o-phenylenediamine are improved; and the o-phenylenediamine is directly prepared from aniline, so the environmental pollution caused by nitrification and chlorination processes is avoided, and the method is more in line with the green andenvironment-friendly synthesis concept.