34805-47-5

Basic information

• Product Name: 5-Nitropentanoic acid methyl ester
• Synonyms: 5-Nitropentanoic acid methyl ester
• CAS NO: 34805-47-5
• Molecular Formula: C₆H₁₁NO₄
• Molecular Weight: 0
• Mol File: 34805-47-5.mol
• Article Data: 6

Chemical Properties

• Appearance: /
• CAS DataBase Reference: 5-Nitropentanoic acid methyl ester(CAS DataBase Reference)
• NIST Chemistry Reference: 5-Nitropentanoic acid methyl ester(34805-47-5)
• EPA Substance Registry System: 5-Nitropentanoic acid methyl ester(34805-47-5)

Safety Data

• Hazardous Substances Data: 34805-47-5(Hazardous Substances Data)

Upstream product

• 19129-92-1 methyl 2-bromovalerate 
• 5454-83-1 5-bromovaleric acid methyl ester 
• 67-56-1 methanol 
• 22498-31-3 2-nitrocyclopentan-1-one 

Downstream Products

• 847266-45-9 4-[5-(2-methoxy-phenyl)-isoxazol-3-yl]-butyric acid methyl ester 
• 6093-95-4 methyl 5-oxodecanoate 
• 85993-92-6 5-nitro PGI₁ 
• 53848-36-5 (E)-5-Nitro-6-phenyl-5-hexensaeuremethylester 

Relevant articles and documents

Activation of Peroxisome Proliferator-Activated Receptor γ (PPARγ) by nitroalkene fatty acids: Importance of nitration position and degree of unsaturation

Nitroalkene fatty acids are potent endogenous ligand activators of PPARγ-dependent transcription. Previous studies with the naturally occurring regioisomers of nitrolinoleic acid revealed that the isomers are not equivalent with respect to PPARγ activation. To gain further insight into the structure-activity relationships between nitroalkenes and PPARγ, we examined additional naturally occurring nitroalkenes derived from oleic acid, 9-nitrooleic acid (E-9-NO2-18:1 [1]) and 10-nitrooleic acid (E-10-NO2-18:1 [2]), and several synthetic nitrated enoic fatty acids of variable carbon chain length, double bonds, and nitration site. At submicromolar concentrations, E-12-NO2 derivatives were considerably more potent than isomers nitrated at carbons 5, 6, 9, 10, and 13, and chain length (16 versus 18) or number of double bonds (1 versus 2) was of little consequence for PPARγ activation. Interestingly, at higher concentrations (>2 μM) the nitrated enoic fatty acids (E-9-NO2-18:1 [1], E-9-NO2-16:1 [3], E-10-NO2-18:1 [2], and E-12-NO 2-18:1 [7]) deviated significantly from the saturable pattern of PPARγ activation observed for nitrated 1,4-dienoic fatty acids (E-9-NO2-18:2, E-10-NO2-18:2, E-12-NO2-18:2, and E-13-NO2-18:2).

COMPOUNDS, METHODS AND FORMULATIONS FOR THE ORAL DELIVERY OF A GLUCAGON LIKE PEPTIDE (GLP)-1 COMPOUND OR AN MELANOCORTIN 4 RECEPTOR (MC4) AGONIST PEPTIDE

The present invention relates to novel compounds, methods, and formulations useful for the oral delivery of a GLP-1 compound or an MC4 agonist peptide.

Pyrrolizidine-3-ones

The present invention provides certain 2,3-didehydro-5-oxopyrrolizidinones and indolizidinones which are useful as lipid-altering and anti-atherosclerotic agents.