34838-64-7

Basic information

• Product Name: (E)-3-Phenyl-1-(4-[(E)-(3-phenyl-acryloyl)]-phenyl)-propenone
• Synonyms: (E)-3-Phenyl-1-(4-[(E)-(3-phenyl-acryloyl)]-phenyl)-propenone
• CAS NO: 34838-64-7
• Molecular Formula: C₂₄H₁₈O₂
• Molecular Weight: 338.39852
• Mol File: 34838-64-7.mol
• Article Data: 7

Chemical Properties

• Boiling Point: 544.6°Cat760mmHg
• Flash Point: 199.8°C
• Appearance: /
• Density: 1.166g/cm³
• CAS DataBase Reference: (E)-3-Phenyl-1-(4-[(E)-(3-phenyl-acryloyl)]-phenyl)-propenone(CAS DataBase Reference)
• NIST Chemistry Reference: (E)-3-Phenyl-1-(4-[(E)-(3-phenyl-acryloyl)]-phenyl)-propenone(34838-64-7)
• EPA Substance Registry System: (E)-3-Phenyl-1-(4-[(E)-(3-phenyl-acryloyl)]-phenyl)-propenone(34838-64-7)

Safety Data

• Hazardous Substances Data: 34838-64-7(Hazardous Substances Data)

Usage

Description

(E)-3-Phenyl-1-(4-[(E)-(3-phenyl-acryloyl)]-phenyl)-propenone, commonly known as chalcone, is a yellow solid chemical compound belonging to the chalcone class of organic compounds. It has a molecular formula of C22H16O2 and a molecular weight of 312.36 g/mol. Chalcone features a distinctive α,β-unsaturated ketone structure, with a central 1,3-diphenylprop-2-en-1-one unit, a substituted phenyl group at the 3-position, and a conjugated phenylacryloyl group at the 1-position. (E)-3-Phenyl-1-(4-[(E)-(3-phenyl-acryloyl)]-phenyl)-propenone is widely recognized for its role as a precursor in the synthesis of flavonoids, which exhibit a range of biological activities such as antioxidant, anti-inflammatory, anti-cancer, and antimicrobial properties.

Uses

Used in Pharmaceutical Research:
Chalcone is utilized as a key intermediate in the synthesis of flavonoids, which are essential in pharmaceutical research due to their diverse biological activities. These flavonoids have potential applications in the development of treatments for various diseases, including their antioxidant, anti-inflammatory, anti-cancer, and antimicrobial properties.
Used in Natural Product Chemistry:
In the field of natural product chemistry, chalcone serves as a valuable compound for the synthesis of flavonoids. These flavonoids are known for their wide range of biological activities, making them important targets for the development of new drugs and therapeutic agents.
Used in the Synthesis of Specific Flavonoids:
Chalcone is used as a precursor for the synthesis of specific flavonoids with potential therapeutic applications. These flavonoids can be further investigated and optimized for their efficacy in treating various diseases and conditions.
Used in Drug Delivery Systems:
Similar to gallotannin, chalcone and its derivatives can be incorporated into drug delivery systems to enhance their bioavailability, delivery, and therapeutic outcomes. This application can improve the overall effectiveness of chalcone-based treatments and expand their use in the pharmaceutical industry.

Upstream product

• 1009-61-6 1,4-Diacetylbenzene 
• 100-52-7 benzaldehyde 
• 1205-91-0 benzene-1,4-diyl diacetate 
• 1065-88-9 p-Terephthaloyl-bis-methylen-triphenylphosphoran 
• 42472-69-5 4-ethynylacetophenone 
• 935-14-8 1,4-diethynylbenzene 
• 103-49-1 dibenzylamine 

Downstream Products

• 132843-97-1 [4-(4-Phenyl-4,5-dihydro-1H-pyrazole-3-carbonyl)-phenyl]-(4-phenyl-4,5-dihydro-1H-pyrazol-3-yl)-methanone 
• 143517-42-4 1,1'-terephthaloylbis<2-phenyl-3-(phenylthio)cyclopropane> 
• 90280-94-7 21,22,23,24-tetraphenyl-1,4,11,14-teraoxo-2(3),12(13)-diethano<4,4>paracyclophane 
• 95363-45-4 C₁₂₀H₉₀O₁₀ 
• 95462-20-7 21,22,23,24-tetraphenyl-1,4,11,14-tetraoxo-2(3),12(13)-diethano<4.4>paracyclophane 
• 95363-43-2 (E)-1-(4-{(1S,3R,4S)-2-[4-((1R,2R,3S,4S)-2,3-Diphenyl-4-{4-[(E)-(3-phenyl-acryloyl)]-benzoyl}-cyclobutanecarbonyl)-benzoyl]-3,4-diphenyl-cyclobutanecarbonyl}-phenyl)-3-phenyl-propenone 
• 95363-44-3 (E)-1-{4-[2-(4-{3-[4-(2,3-Diphenyl-4-{4-[(E)-(3-phenyl-acryloyl)]-benzoyl}-cyclobutanecarbonyl)-benzoyl]-2,4-diphenyl-cyclobutanecarbonyl}-benzoyl)-3,4-diphenyl-cyclobutanecarbonyl]-phenyl}-3-phenyl-propenone 
• 95363-46-5 C₁₄₄H₁₀₈O₁₂ 
• 143517-55-9 1,1'-terephthaloylbis<2-phenyl-3-(phenylsulfonyl)cyclopropane> 

Relevant articles and documents

Phosphorous Acid Promoted Hydration-Condensation of Aromatic Alkynes with Aldehydes Affording Chalcones in an Oil/Water Two-Phase System

A simple and environmentally benign method was developed for the synthesis of chalcones in high to excellent yields by a phosphorous acid promoted alkyne-aldehyde hydration-condensation in an oil/water two-phase system. The method is the first efficient protocol for the preparation of chalcones that is mediated by a simple Bronsted acid in a two-phase system.

Practical metal-free synthesis of chalcone derivatives via a tandem cross-dehydrogenative-coupling/elimination reaction

Metal-free synthesis of chalcone derivatives through a tandem cross-dehydrogenative-coupling/elimination reaction is described. A simple and inexpensive ammonium persulfate salt enables the reaction between ketones and benzylamines to proceed with high stereoselectivity and good functional group compatibility.

Convergence of absorption and fluorescence in cross-conjugated oligomers consisting of chalcone building blocks

The absorption and fluorescence spectra of two series of chalcone oligomers (1a-d) and (2a-d) are reported. Due to small or vanishing orbital coefficients (HMO calculation) within the cross-conjugated systems, the bathochromic shifts caused by the extensi